Immunohistochemical Distribituon of COX-1, COX-2, and TGF beta-1 in the Duodenum of Rats Treated with Capsaicin
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Date
2016
Journal Title
Journal ISSN
Volume Title
Publisher
Kafkas Univ, Veteriner Fakultesi Dergisi
Access Rights
info:eu-repo/semantics/openAccess
Abstract
The purpose of this study was to investigate the effects of capsaicin on the duodenal distribution of cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Transforming growth factor beta-1 (TGF beta-1) in rats. Rats were divided into two groups (n = 10 in each group). Experimental group treated with capsaicin (1 mg/kg, subcutaneously) was injected in 10% ethanol, 1% Tween and 80% distilled water everyday for a period of one week and in not injected control group. Localisations of COX-1, COX-2 and TGF beta-1 were observed in villus and crypt ephitelial cells, and smooth muscle cells. In conclusion, in this study, capsaicin administration was found to increase the release of COX-1 and COX-2, and TGF beta-1.
Description
Keywords
Capsaicin, Cyclooxygenase, Duodenum, Transforming growth factor beta-1, Growth-Factor-Alpha, Epithelial-Cells, Factor-Beta, Cyclooxygenase 2, Gene-Expression, Pain Management, Small-Intestine, Messenger-Rna, Receptor, Mice
Journal or Series
Kafkas Universitesi Veteriner Fakultesi Dergisi
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
22
Issue
3
