Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0001-5590-0637
dc.authorid0000-0002-8084-7855
dc.authorid0000-0002-1224-442X
dc.authorscopusid56674583800
dc.authorscopusid35197435300
dc.authorscopusid7005912992
dc.authorscopusid56674439000
dc.authorscopusid35076796400
dc.authorscopusid56769801000
dc.authorscopusid56250943500
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidKARAARSLAN, Numan/I-6819-2019
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidOzbek, Hanefi/O-3472-2019
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorTopuk, Savas
dc.contributor.authorYasar Şirin, Duygu
dc.contributor.authorAteş, Özkan
dc.date.accessioned2022-05-11T14:12:15Z
dc.date.available2022-05-11T14:12:15Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractAIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field worldwide in the last 31 years. MATERIAL and METHODS: Articles about clinical trials conducted between December 1, 1949 and November 8, 2017, were identified from the Cochrane Collaboration, the Cochrane Library, Ovid MEDLINE, ProQuest, the National Library of Medicine, and PubMed electronic databases, using the terms post transcriptional gene silencing, small interfering RNA, siRNA, and glioblastoma, either individually or combined (OR and AND), without language and country restrictions. Articles that met the examination criteria were included in the study. After descriptive statistical evaluation, the results were reported in frequency (%). RESULTS: After scanning 2.752 articles, five articles were found that met the research criteria. Examination of full texts of the five identified articles provided no sufficient evidence for research conducted with regard to the use of gene silencing via siRNAs in glioblastoma treatment. CONCLUSION: To be able to evaluate the clinical use of siRNAs, there is an urgent need for in vivo studies and for trials with randomized, controlled, and clinical designs that provide long-term functional outcomes.
dc.identifier.doi10.5137/1019-5149.JTN.22467-18.3
dc.identifier.endpage334
dc.identifier.issn1019-5149
dc.identifier.issue3en_US
dc.identifier.pmid29694664
dc.identifier.scopus2-s2.0-85065877677
dc.identifier.scopusqualityQ3
dc.identifier.startpage328
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.22467-18.3
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5466
dc.identifier.volume29
dc.identifier.wosWOS:000466983900003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorÇalışkan, Tezcan
dc.institutionauthorYasar Şirin, Duygu
dc.language.isoen
dc.publisherTurkish Neurosurgical Soc
dc.relation.ispartofTurkish Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBrain tumor
dc.subjectGlioblastoma
dc.subjectPosttranscriptional gene silencing
dc.subjectsiRNA vector
dc.subjectHigh-Grade Glioma
dc.subjectPrognostic-Factors
dc.subjectMalignant Glioma
dc.subjectTemozolomide
dc.subjectExpression
dc.subjectPathways
dc.subjectCells
dc.subjectKnockdown
dc.subjectRadiation
dc.subjectApoptosis
dc.titleSystematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma
dc.typeArticle

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