Systematic Evaluation of Promising Clinical Trials-Gene Silencing for the Treatment of Glioblastoma
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Turkish Neurosurgical Soc
Access Rights
info:eu-repo/semantics/openAccess
Abstract
AIM: To systematically investigate the role of artificial small interfering RNA (SiRNA) molecules in glioblastoma treatment and to give a detailed overview of the literature concerning studies performed in this field worldwide in the last 31 years. MATERIAL and METHODS: Articles about clinical trials conducted between December 1, 1949 and November 8, 2017, were identified from the Cochrane Collaboration, the Cochrane Library, Ovid MEDLINE, ProQuest, the National Library of Medicine, and PubMed electronic databases, using the terms post transcriptional gene silencing, small interfering RNA, siRNA, and glioblastoma, either individually or combined (OR and AND), without language and country restrictions. Articles that met the examination criteria were included in the study. After descriptive statistical evaluation, the results were reported in frequency (%). RESULTS: After scanning 2.752 articles, five articles were found that met the research criteria. Examination of full texts of the five identified articles provided no sufficient evidence for research conducted with regard to the use of gene silencing via siRNAs in glioblastoma treatment. CONCLUSION: To be able to evaluate the clinical use of siRNAs, there is an urgent need for in vivo studies and for trials with randomized, controlled, and clinical designs that provide long-term functional outcomes.
Description
Keywords
Brain tumor, Glioblastoma, Posttranscriptional gene silencing, siRNA vector, High-Grade Glioma, Prognostic-Factors, Malignant Glioma, Temozolomide, Expression, Pathways, Cells, Knockdown, Radiation, Apoptosis
Journal or Series
Turkish Neurosurgery
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
29
Issue
3
