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    A New Insulin Sensitivity Index Derived From Fat Mass Index and Quantitative Insulin Sensitivity Check Index
    (Namık Kemal Üniversitesi, Tıp Fakültesi, 2015) Donma, Mustafa Metin; Donma, Orkide; Topçu, Birol; Aydın, Murat; Tülübaş, Feti; Nalbantoğlu, Burçin; Demirkol, Muhammet; Gürel, Ahmet
    Aim Obesity has recently become one of the most important health problems throughout the world. This fact led to the controversies on the clinical use of insulin sensitivity indices. Indices previously described or introduced in this study have been evaluated to choose one, which is capable of exhibiting significant distinctions between healthy children and those involved in the classes of childhood obesity. Material and Methods A total of 179 girls; 81 morbidly obese(MO), 42 obese(O), 16 overweight(OW) and 40 normal(N) participated in the study. Groups were constituted based upon age- and sex-specific body mass index percentiles tabulated by World Health Organization. Homeostasis Model Assessment of Insulin Resistance(HOMA-IR), HOMA-IR/BMI, log HOMA-IR, fasting glucose/fasting insulin ratio(FGIR), quantitative insulin sensitivity check index(QUICKI), Raynaud, reciprocal insulin indices and also new indices HOMAIR*BMI, HOMA-IR*fat mass index(FMI), QUICKI*BMI, QUICKI*FMI were calculated. The cut-offs 3.16 and 2.5 for HOMA-IR, 7 and 6 for FGIR, 0.357 and 0.328 for QUICKI were evaluated to estimate insulin resistance. Statistical analyses were performed with Predictive Analytics SoftWare(PASW) Statistics 18. Results and Conclusion QUICKI*FMI was able to make a clear-cut separation between the groups. A new trilogy for cut-offs (HOMA>2.5, FGIR<7, QUICKI<0.328); each giving the similar results, has been suggested. Multifaceted character of QUICKI was also introduced. QUICKI was capable of discriminating MO from O when 0.328 cutoff was used, and O from OW when 0.357 cut-off was used. QUICKI*FMI index, a new one, was unique in detecting the advanced level of differences(p?0.005) between N-OW, OW-O and O-MO groups during childhood obesity.
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    A post-treatment evaluation of total IgE, CRP and blood count parameters of children with asthma
    (2013) Tülübaş, Feti; Gürel, Ahmet; Donma, Mustafa Metin; Nalbanto?lu, Burçin; Topçu, Birol; Yıldız, Zeynep Deniz
    Objective: We aimed to study if inhaled corticosteroid and inhaled beta 2 agonist treatment to 2-18 years old children with asthma resulted in recovery in serum total IgE, CRP, and whole blood count levels and/or to evaluate the effect of treatment in comparison to healthy children. Methods: Data regarding pre and post treatment serum total IgE, CRP, and hemogram levels of 2-18 years old, 99 children with asthma, who received inhaled corticosteroid and inhaled beta 2 agonist treatment and who applied to Nami{dotless}k Kemal University Research and Practice Hospital Pediatrics Clinic, were obtained through file scanning. Data regarding demographics and serum total IgE, CRP and hemogram levels of 99 healthy children in control group were also obtained through file scanning. Results: In children with asthma, levels of serum total IgE, lymphocyte, eosinophil and basophil counts and percentages were significantly increased compared to healthy controls, and they were significantly decreased after treatment to the levels of healthy controls. Serum CRP levels, neutrophil counts and percentages were significantly decreased compared to healthy controls, and they were significantly increased after treatment. Conclusions: Inhaled steroid and beta 2 antagonist treatment to children with asthma resulted in recovery in levels of IgE, CRP, and some whole blood count parameters through decreasing inflammation with its anti-inflammatory effect.
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    A rare association: Unilateral fibromatosis colli and contralateral clavicle fracture in a newborn
    (Elsevier Ireland Ltd, 2015) Donma, Mustafa Metin; Demirkol, Muhammet; Yıldırım Güzelant, Aliye; Özçağlayan, Ömer; Gülek, B.; Karakoyun, Özgür; Donma, Orkide
    Fibromatosis colli (FC) is a cause of muscular torticollis that can be diagnosed by careful physical examination. In most of the cases, follow up and exercise is enough for treatment, although rare cases require surgical intervention. Clavicle fracture can be a complication of struggling vaginal parturition and usually treated by close follow up. This case was reported and discussed as a rare association that is not found in the literature and the first case diagnosed in the newborn period with unilateral FC associated with contralateral clavicle fracture in a non-macrosomic infant who was treated with dramatic response to physical therapy. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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    Asprosin: Possible target in connection with ghrelin and cytokine network expression in the post-burn treatment
    (Churchill Livingstone, 2018) Donma, Mustafa Metin; Donma, Orkide
    Burn injury is a severe form of trauma associated with pain, metabolic abnormalities, susceptibility to infections, muscle loss, mental and emotional distress. Conventional therapies as well as some recent approaches for the treatment of burned patients are currently in use. Nutritional therapy is also suggested as a supplementary option in major burns. Within this context, hormones involved in the regulation of appetite will have a paramount importance. The aim is to evaluate the interactions among ghrelin, some inflammatory parameters and the burn injury. Asprosin is also involved into this discussion due to its ghrelin-like actions. Aside from the consideration of insulin as well as stress hormones (cortisol, epinephrine, norepinephrine), an orexigenic, anti-inflammatory hormone, ghrelin affecting both metabolic and inflammatory systems is also involved in the protocols designed for burn treatment. Ghrelin's actions exerted by way of growth-hormone secretagogue receptor, neuropeptide Y, agouti-related protein, proopiomelanocortin and gamma amino butyric acid are being investigated. Asprosin, one of the remarkably few hormones identified as appetite stimulator, acts as another orexigenic hormone by using almost the same signalling pathways as those of ghrelin. Interleukin-6 should also be evaluated both as a reliable biomarker of inflammation and also with its inhibitory effects on TNF-alpha within the scope of burn injury. In conclusion, treatment protocols during burn injury may be designed to raise decreased concentrations of ghrelin and to repress increased levels of inflammatory agents such as TNF-alpha. IL-6 may be evaluated from an entirely different aspect. The potential therapeutic use of asprosin may be considered within an integrative approach with a focus on cachexia-anorexia developed in severe burn trauma.
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    ASSOCIATION OF DEPRESSION AND TRACE ELEMENTS IN OBESE CHILDREN
    (Namık Kemal Üniversitesi, Tıp Fakültesi, 2017) Donma, Mustafa Metin; Donma, Orkide
    Depression, anxiety disorders, learning disability are common problems requiring pediatric care and found to be associated with obesity. Elevated and reduced levels of trace elements may be indicators of depression. Deficiencies or toxicities of some elements may also cause weight gain leading obesity, which is a health problem increasing worldwide particularly among children and adolescents. In this review, the physical and mental health consequences of pediatric and adolescent obesity will be evaluated from the trace elements point of view. Better understanding of the participation of trace elements in the metabolic pathways related to neurophysiological processes, their interactions and cumulative effects will help to improve health and also the effects of treatment.
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    Association of fetuin a, adiponectin, interleukin 10 and total antioxidant capacity with IVF outcomes
    (Research and Clinical Center for Infertitlity, 2014) Yen, Mustafa; Donma, Orkide; Yıldızfer, Ferdağ; Ekmekci, Özlem; Karataş Kul, Zübeyde Aslı; İmal, A. Esat; Donma, Mustafa Metin
    Background: Possible roles of anti-inflammatory factors as well as total antioxidative capacity in reproductive processes of women undergoing in vitro fertilization (IVF) are still being investigated and the contributions by some of them remain controversial. Objective: The aim of this study is to investigate the relationship between antiinflammatory parameters and total antioxidative capacity (TAC) of the body during IVF. In this respect, adiponectin, interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1RA), fetuin A and TAC analyses have been performed. Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (Group-1), and 26 infertile women before (Group-2) and after (Group-3) IVF treatment were analyzed. IL-1RA, IL-10, fetuin A, adiponectin and insulin were determined by ELISA. TAC was determined spectrophotometrically. Mann-Whitney U test, paired sample t-test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: Clinical pregnancy and live birth rates were determined as 30.8% and 23.1%, respectively, in pregnant group. For the pregnant, significant indirect correlations were detected between fetuin A and adiponectin (r=-0.843; p=0.035) as well as IL-10 (r=-0.846; p=0.034) in Group 2. The correlation between adiponectin and IL-10 doubled in pregnant compared to non-pregnant (r=0.929; p=0.007 vs. r=0.478; p=0.033). The correlations between fetuin A and TAC in pregnant were noted both in Group 2 (r=0.892; p=0.017) and Group 3 (r=0.875; p=0.022). No correlation of fetuin A with these parameters was detected in non-pregnant group. Conclusion: Fetuin A, TAC, IL-10, adiponectin and their associations may be important from their predictive values for IVF success point of view. Parameters with anti-inflammatory or antioxidant property appear to improve pregnancy in women undergoing IVF. © Research and Clinical Center for Infertitlity. All rights reserved.
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    Association of Thiol Disulfide Homeostasis with Childhood Asthma
    (Georg Thieme Verlag Kg, 2016) Kaya, Buket Kubra; Aydın, Murat; Donma, Mustafa Metin; Demirkol, Muhammet; Biçer, Cemile; Erel, Özcan
    The aim of this study is to evaluate the oxidative stress level in asthmatic children in terms of the disulfide/thiol ratio, to research the role the disulfide/thiol ratio plays in the pathogenesis of the malady, and to determine the usefulness of the disulfide/thiol ratio as an indicator of the oxidation stress situations in patients with asthma. We report that the disulfide/thiol ratio and disulfide levels were significantly higher in the asthmatic group than in the control group. All in all, high levels of disulfide/thiol ratios in asthmatic children are thought to play roles in the pathogenesis of the disease.
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    Astma ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi
    (2013) Tülübaş, Feti; Gürel, Ahmet; Donma, Mustafa Metin; Nalbantoğlu, Burçin; Topçu, Birol; Mut, Zeynep Deniz
    Amaç: Bu çalışmanın amacı; astım ve alerjik rinit tanısı alan çocukların total IgE, C reaktif protein (CRP) ve tamkan sayım parametrelerinin hastalık ile ilişkilerinin olup olmadığını retrospektif olarak araştırmaktır.Gereç ve Yöntem: Hastanemiz Çocuk Sağlığı ve Has- talıkları polikliniğine gelen 2-18 yaş arası toplam 443 ço- cuğun retrospektif taraması yapıldı. Muayene sonuçları- na göre çocuklar astım (n=179), alerjik rinit (n=171) ve kontrol grubu (n=93) olarak üçe ayrıldı. Her gruptaki ço- cukların serum total IgE ve CRP düzeyleri ile hemogram değerleri, yaş ve cinsiyetleri kaydedildi. Bulgular: Astım grubunda eozinofil sayısı, MCHC ve total IgE düzeyleri kontrol grubuna göre anlamlı olarak artar- ken, MCV düzeyi azalmıştır. Alerjik rinit grubunda lenfosit sayısı, CRP ve total IgE düzeyleri kontrol grubuna göre anlamlı olarak artarken nötrofil sayısı azalmış, eozinofil sayısında ise anlamlı bir değişiklik gözlenmemiştir. Sonuçlar: Bu sonuçlar; astım patagonezinde etkili olan faktörlerin eritrosit morfolojisi üzerine de etkili olduğunu düşündürmektedir. Ayrıca, astımda kan eozinofil düzeyin- deki değişiklikler, alerjik rinitte ise nötrofil ve lenfosit düze- yindeki değişikler dikkat çekmekte olup, astımda serum total IgE düzeylerinde, alerjik rinitte ise CRP düzeylerinde artış saptanmıştır.
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    Asymmetric dimethylarginine as risk marker of endothelial dysfunction in obese children
    (Wiley-Blackwell, 2016) Aydın, M.; Donma, Mustafa Metin; Donma, Orkide; Nalbantoğlu, Burçin; Tülübaş, Feti; Topçu, Birol; Gürel, A.; Demirkol, Muhammet; Yılmaz, A.; Küçükyalçın, V.
    [No Abstract Available]
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    CD4(+), CD25(+), FOXP3(+) T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children
    (Springer/Plenum Publishers, 2015) Donma, Mustafa Metin; Karasu, Erkut; Özdilek, Burcu; Turgut, Burhan; Topçu, Birol; Nalbanto?lu, Burçin; Donma, Orkide
    The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this study. Blood samples collected from children were marked with CD4, CD25, ve Foxp3 in order to detect Tregs and Ths by flow cytometric method. Statistical analyses were performed. p a parts per thousand currency signaEuro parts per thousand 0.05 was chosen as meaningful threshold. Tregs exhibiting anti-inflammatory nature were significantly lower in obese (0.16 %; p a parts per thousand currency signaEuro parts per thousand 0.001), asthmatic (0.25 %; p a parts per thousand currency signaEuro parts per thousand 0.01), and asthmatic obese (0.29 %; p a parts per thousand currency signaEuro parts per thousand 0.05) groups than control group (0.38 %). Ths were counted higher in asthma group than control (p a parts per thousand currency signaEuro parts per thousand 0.01) and obese (p a parts per thousand currency signaEuro parts per thousand 0.001) groups. T cell immunity plays important roles in chronic inflammatory diseases such as obesity and asthma pathogeneses. Decreased numbers of Tregs found in obese, asthmatic, and asthmatic obese children might represent a challenge of these cells.
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    Çocuklarda kilo fazlalığının kalp fonksiyonlarına etkisi
    (2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbantoğlu, Burçin; Topçu, Birol; Değirmenci, Hasan; Donma, Mustafa Metin
    Amaç: Obezitenin kalp yetersizliği riski ile ilişkili olduğu bilinmektedir. Semptomsuz sol ventrikül (SV) diyastolik fonksiyon bozukluğu kalp yetersizliği gelişmesi ile ilişkilidir. Çocuklarda kilo fazlalığının subklinik SV diyastolik fonksiyon bozukluğu ile ilişkili olup olmadığı belli değildir. Bu çalışmanın amacı kilolu çocuklarda SV kitle indeksi ve SV diyastolik fonksiyonları üzerine beden kütle indeksi (BKİ) ve bel çevresinin etkisini değerlendirmektir. Çalışma planı: Çalışmaya normal kilolu (yaşa göre ayarlanmış BKİ: %15-85 arası) 91 ve fazla kilolu (yaşa göre ayarlanmış BKİ: %85-95 arası) 61 olmak üzere toplam 153 çocuk katıldı. İki boyutlu, M-Mode görüntüleme ile boyutlar ve çaplar ölçüldü. SV diyastolik fonksiyonu geleneksel ve doku Doppler görüntüleme ile değerlendirildi. Bulgular: Kilolu çocuklarda yüksek yoğunluklu kolesterol düşük, sistolik ve diyastolik kan basıncı (KB), serum insülini, HOMA indeksi, trigliserit (TG), sol atriyum, aort ve SV çapları, SV duvar kalınlıkları, sol ventrikül kitlesi (SVK) ve sol ventrikül kitle indeksi (SVKİ) fazla idi. Mitral anülüs septal e, septal e/a, lateral e, lateral e/a, triküspit lateral anülüs e ve e/a değerleri düşüktü. Mitral anülüs septal e, lateral e, triküspit lateral anülüs e, mitral anülüs septal e/a, lateral e/a ve triküspit lateral anülüs e/a ile BKİ, bel çevresi, serum insülin düzeyi, HOMA indeksi, sistolik ve diyastolik KB arasında negatif korelasyon bulundu. SVKİ ile BKİ ve bel çevresi arasında pozitif korelasyon bulundu. Mitral anülüs septal e, septal e/a, lateral e, lateral e/a için sadece BKİ öngördürücü olarak tespit edildi. Sonuç: Normal kilolu çoçuklara kıyasla kilolu çocuklarda SV diyastolik fonksiyonlarında azalma vardır. Kilolu çocuklarda BKİ, SV diyastolik fonksiyonlarında azalma ile ilişkilidir.
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    Çocuklarda Obezitenin Sol Ventrikül Diyastolik Fonksiyonları Üzerine Etkisi
    (2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbantoğlu, Burçin; Topçu, Birol; Değirmenci, Hasan; Donma, Mustafa Metin
    Amaç: Bu çalışmada obez ve normal kilolu çocuklarda iki boyutlu, M-Mod, geleneksel ve doku Doppler ekokardiyografi yle sol ventrikül diyastolik fonksiyon parametrelerini ölçmeyi ve bu parametreler üzerine antropometrik ve biyokimyasal faktörlerin etkilerini değerlendirmeyi amaçladık.Hastalar ve Yöntem: Bu olgu-kontrollü kesitsel çalışmaya, 8-15 yaş arası 60 obez ve 60 normal kilolu çocuk dahil edildi. Çocukların antropometrik ve biyokimyasal değerleriyle sol ventrikül ekokardiyografi k parametreleri ölçüldü ve aralarındaki ilişki araştırıldı.Bulgular: Obez grupta bel çevresi ve beden kitle indeksi (BKİ-Z) skoru, sistolik ve diyastolik kan basıncı, trigliserid, açlık kan şekeri, insülin ve homeostatik modeli değerlendirmesi (HOMD) indeksi anlamlı olarak yüksekken yüksek yoğunluklu lipoprotein kolesterol (YYL-K) konsantrasyonu anlamlı derecede düşük bulundu. Mitral annulus septal E' ve E'/A', mitral annulus lateral E' ve E'/A', anteriyor E' ve E'/A', inferiyor E' ve E'/A' değerleri anlamlı derecede düşük bulundu, mitral E'/septal E' ve mitral E/lateral E değerleri anlamlı olarak daha yüksekti. Çoğu doku Doppler parametreleri ile bel çevresi, BKİ-Z skoru, açlık kan şekeri, HOMD, serum insülin düzeyi sistolik ve diyastolik kan basıncı, trigliserid ve YYL-K arasında korelasyon vardı. Bel çevresi ve BKİ-Z skoru bazı doku Doppler parametreleri için belirleyiciydi.Sonuç: Obez çocuklarda akranlarına göre sol ventrikül diyastolik fonksiyonları bozulmuştur. Risk faktörleriyle diyastolik fonksiyon parametreleri arasında korelasyon olsa da, obezitenin kendisi sol ventrikül diyastolik fonksiyonlarında azalmayla ilişkilidir.
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    Copeptin as a Novel Biomarker in Nocturnal Enuresis [reply]
    (Elsevier Science Inc, 2013) Nalbanto?lu, Burçin; Donma, Mustafa Metin; Özdilek, Burcu; Mintaş, Nuriye Ece; Yazıcı, Cenk Murat; Nalbantoğlu, Ayşin; Güzel, Eda Çelik
    [No Abstract Available]
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    Decreased serum orexin A levels in drug-naive children with attention deficit and hyperactivity disorder
    (Springer-Verlag Italia s.r.l., 2019) Baykal, S.; Albayrak, Yakup; Durankuş, Ferit; Güzel, S.; Abbak, Özlem; Potas, Nihan; Donma, Mustafa Metin
    Attention deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders of childhood and characterized by inattention, hyperactivity, and impulsivity. ADHD is a neurodevelopmental disorder, and its etiology has not yet been determined precisely. Orexin A is thought to play an important role in different forms of learning, memory, and attention. Despite its importance in attention and learning, no study has investigated serum orexin levels in patients with ADHD. In the present study, we aimed to compare serum orexigenic neuropeptides such as orexin A and orexin B, neuropeptide Y, and ghrelin between drug naive children with ADHD and healthy children. Fifty-six drug-naive children with ADHD and 40 healthy controls were enrolled in the study. After comparison of serum orexin A and orexin B, neuropeptide Y, and ghrelin, we found that serum orexin A levels were significantly lower in the ADHD group (p = 0.001). Furthermore, serum orexin A levels were compared between ADHD subgroups. Orexin A levels were significantly lower in the inattentive subtype compared with the hyperactive subtype and combined subtype (p = 0.009). Our results indicate that orexin A might be a neurobiological etiological factor in ADHD, particularly associated with attention symptoms. The present study is the first to demonstrate decreased serum orexin A levels in drug-naive children with ADHD. Further studies are needed to confirm our results and to show the effects of treatments involving orexin A in patients with ADHD. © 2019, Fondazione Società Italiana di Neurologia.
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    Does Low Birth Weight Affect P-Wave and QT Dispersion in Childhood?
    (Wiley, 2013) Akyüz, Aydın; Alpsoy, Şeref; Akkoyun, Dursun Çayan; Nalbanto?lu, Burçin; Özdilek, Burcu; Donma, Mustafa Metin
    BackgroundThe aim of our study is to investigate the effects of low birth weight (LBW) on atrial conduction and ventricular repolarization in children by using P-wave dispersion (Pw-d) and QT dispersion (QT-d) analyses. These effects have not yet been studied in detail in LBW children. MethodsFifty LBW children and 70 normal birth weight (NBW) children were enrolled in this cross-sectional controlled study. The Pw-d and QT-d of the LBW and NBW children were investigated. Independent Student's t-test, Mann-Whitney U test, and (2) test were performed to compare these two groups. Stepwise multiple regression analysis was performed to investigate whether there was a relationship between P-wave indices, QT derivatives, anthropometric and clinical features, and echocardiographic parameters. ResultsAge, gender, body mass index, waist circumferences, systolic and diastolic blood pressure, and echocardiographic measurements were similar between the LBW group and the NBW group (all P values > 0.05). The following findings were recorded for the LBW and NBW groups, respectively: the Pw-d (30 [10-50] ms vs 30 [10-50] ms, P = 0.977), QT-d (20 [10-50] ms vs 30 [15-50] ms, P = 0.561), and QTc-d (26 [14-54] ms vs 33 [17-62] ms, P = 0.866). No significant difference was found in Pw-d, QT-d, and QTc-d in comparison between the groups (all P values > 0.05). Pw-d was related to left atrial diameter and QTc-d was associated with left ventricle mass index even though they were within the normal range. ConclusionCompared with the NBW group, no significant difference was found in both atrial conduction and ventricular repolarization features in LBW children.
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    Effect of Obesity on Endothelial Function and Subclinical Atherosclerosis in Children
    (Modestum Ltd, 2014) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbanto?lu, Burçin; Topçu, Birol; Donma, Mustafa Metin
    We aimed to measure flow-mediated dilation (FMD), carotid intima-media thickness (cIMT), and to evaluate the effects of waist circumference (WC), and body mass index Z (BMI-Z) score on these parameters in obese children. This case-control cross-sectional study included 70 obese and 40 non-obese children aged 7-14 years who presented with various complaints and had no concomitant diseases. FMD and cIMT were measured in all subjects and correlated with anthropometric and biochemical factors. WC, BMI-Z score, systolic and diastolic blood pressure (BP), triglyceride (TG) and insulin concentrations, and homeostatic model assessment (HOMA) index were significantly higher, whereas high density lipoprotein (HDL) -cholesterol concentration was significantly lower in the obese than in the non-obese group. FMD values were significantly lower, whereas cIMT values were significantly higher in obese than in non-obese subjects. FMD negatively correlated with WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride but positively with HDL-cholesterol. cIMT positively correlated with WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride but negatively with HDL-cholesterol. Increased WC, BMI-Z score, serum insulin level, HOMA, systolic BP, triglyceride and decreased HDL-cholesterol in obese children contribute to endothelial dysfunction and early subclinical atherosclerosis compared to their normal weight peers.
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    Effect of Obesity on Endothelial Function and Subclinical Atherosclerosis in Children (Meeting Abstract)
    (Elsevier Science Inc, 2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbantoğlu, Burçin; Topçu, Birol; Donma, Mustafa Metin; Erselcan, Kubilay
    [No Abstract Available]
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    Effect of overweight on cardiac function in children
    (Turkish Soc Cardiology, 2013) Alpsoy, Şeref; Akyüz, Aydın; Akkoyun, Dursun Çayan; Nalbanto?lu, Burçin; Topçu, Birol; Değirmenci, Hasan; Donma, Mustafa Metin
    Objectives: It is known that obesity is related to heart failure. Asymptomatic left ventricular diastolic dysfunction (LVDD) is associated with the development of heart failure. The relationship between subclinical LVDD and overweight in children is not clear. The purpose of this study was to evaluate the effect of body mass index (BMI) and waist circumference on left ventricular mass index (LVMI) and LVDD in overweight children. Study design: A total of 153 children were enrolled in the study. Of these, 91 were normal weight (age-adjusted BMI: 15-85 percentile), and 62 were overweight (age-adjusted BMI: 85-95 percentile). After measuring two-dimensional and M-mode echocardiographic variables, left and right ventricle diastolic functions were assessed by conventional and tissue Doppler imaging. Results: Compared to controls, overweight children had increased left atrium, aortic and left ventricular diameters, left ventricular wall thickness, LVM and LVMI, and septal mitral annulus e', septal e'/a', lateral e', lateral e'/a', lateral tricuspid annulus e', and e'/a' values. There were negative correlations between tissue Doppler diastolic parameters (septal mitral annulus e', lateral mitral annulus e', lateral tricuspid annulus e', septal mitral annulus e'/a', lateral mitral annulus e'/a', and lateral tricuspid annulus e'/a') and BMI, waist circumference, insulin, HOMA index, as well as systolic and diastolic blood pressure. Positive correlations were found between LVMI and BMI and between LVMI and waist circumference. BMI was found to be the predictor of decreased mitral anulus septal e', septal e'/a', lateral e', lateral e'/a'. Conclusion: Compared with normal-weight children, overweight children have decreased LV diastolic function. BMI is associated with a reduction in LV diastolic function in overweight children.
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    Effect of overweight on P-wave and QT dispersions in childhood
    (Turkish Soc Cardiology, 2013) Akyüz, Aydın; Alpsoy, Şeref; Akkoyun, Dursun Çayan; Nalbanto?lu, Burçin; Tülübaş, Feti; Karasu, Erkut; Donma, Mustafa Metin
    Objectives: The effects of obesity on atrial conduction and ventricular repolarization have been studied in detail, but these parameters have not been well documented in overweight children. The aim of our study was to investigate the effects of overweight on atrial conduction and ventricular repolarization in children by using P-wave dispersion (Pw-d) and QT dispersion (QT-d) analyses. Study design: Sixty-seven overweight children and 70 children within normal limits were included in this cross-sectional prospective controlled study. All subjects underwent electrocardiographic and anthropometric evaluation, and blood samples were obtained. Pw-d and QT-d were investigated between two groups. Results: Homeostatic model assessment of insulin resistance levels were higher in the overweight group (2.9 +/- 1.2 vs. 1.1 +/- 0.8, p=0.001). No statistically significant differences were found in Pw-d and QT-d when the groups were compared. The following findings were recorded for the overweight and control groups, respectively: mean RR interval (635 +/- 42 msec vs. 645 +/- 45 msec, p=0.867), Pw-d [30 (1055) msec vs. 27.5 (15-50) msec, p=0.441] and QT-d (30 (15-55) msec vs. 22.5 (10-60) msec, p=0.476). In addition, Pw-d and QT-d were not correlated with the levels of insulin or body mass index. Conclusion: There was no significant difference in atrial conduction or ventricular repolarization features between overweight children and normal-weight children.
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    Effect of Use of Mobile Phone And Electronic Devices in The Childhood And Adolescence on Body Mass Index And Sleep Time As Well As Fast-Food Consumption And Physical Activity
    (Namık Kemal Üniversitesi, Tıp Fakültesi, 2014) Muhderem, Nazlı; Demirkol, Muhammet; Topçu, Birol; Beldek, Kader; Nergiz, Merve; Çömlek, Büşra; Yorganlı, Ece; Sevinç, Erva; Acar, Çiğdem; İsmailoğlu, İbrahim Halil; Özcan, Selin; Donma, Orkide; Donma, Mustafa Metin
    Aim In this study, we aimed to find out the effects of use of mobile phone (MP)’s and electronic device (ED)’s on body mass index(BMI), sleep-time, consumption of fast-food (FF) and exercise-period of children and adolescents. Material and Methods Questionnaires were applied related to time-periods of MPs/EDs, sleeping and exercise plus FF consumption. Weight, height, waist and hip circumferences were taken. Data of 50 cases using MPs and data of 50 cases who do not use MPs were compared. PASW-18 statistics program, chi-square, independent sample and Mann-Whitney U Test were used. p?0,05 was accepted as statistically significance value. Results Boy/girl ratio was 1/1 in MP(-) group, and it was 0,92 in CT(+) group. Mean age was 121.32±21.22 in MP(-) group, and it was 147.34±24.63 in MP(+) group. Daily usage period of EDs was 234.10±114.49 in MP(-) group, and it was 286.70±116.32 in MP(+) group (p?0,05). BMI of MP(-) group was 19.01±5.08; and it was 20.88±4.74 in the MP(+) group (p?0.05). Daily sleep-time was 9.42±1.08 in the MP(-) group, and it was 8.74±1.06 in the MP(+) group (p?0.05). Weekly frequency of consumption of FF and sweetened-foods in MP(-) group was 2.38±2.85; and it was 5.14±6.93 in the MP(+) group (p?0,01). Daily active-period of MP(-) group was 147.74±254.04, and it was 95.60±64.77 in the MP(+) group (p?0.05). Conclusion Our study emphasizes that decreasing the time spent with EDs, especially with MPs, can be beneficial for minimizing consumption of FF and sweetened foods, prevention of development of obesity, maximizing the time for physical activity and providing optimum sleep time period in children and adolescents.