Çocuklarda Obezitenin Sol Ventrikül Diyastolik Fonksiyonları Üzerine Etkisi
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Dosyalar
Tarih
2013
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada obez ve normal kilolu çocuklarda iki boyutlu, M-Mod, geleneksel ve doku Doppler ekokardiyografi yle sol ventrikül diyastolik fonksiyon parametrelerini ölçmeyi ve bu parametreler üzerine antropometrik ve biyokimyasal faktörlerin etkilerini değerlendirmeyi amaçladık.Hastalar ve Yöntem: Bu olgu-kontrollü kesitsel çalışmaya, 8-15 yaş arası 60 obez ve 60 normal kilolu çocuk dahil edildi. Çocukların antropometrik ve biyokimyasal değerleriyle sol ventrikül ekokardiyografi k parametreleri ölçüldü ve aralarındaki ilişki araştırıldı.Bulgular: Obez grupta bel çevresi ve beden kitle indeksi (BKİ-Z) skoru, sistolik ve diyastolik kan basıncı, trigliserid, açlık kan şekeri, insülin ve homeostatik modeli değerlendirmesi (HOMD) indeksi anlamlı olarak yüksekken yüksek yoğunluklu lipoprotein kolesterol (YYL-K) konsantrasyonu anlamlı derecede düşük bulundu. Mitral annulus septal E' ve E'/A', mitral annulus lateral E' ve E'/A', anteriyor E' ve E'/A', inferiyor E' ve E'/A' değerleri anlamlı derecede düşük bulundu, mitral E'/septal E' ve mitral E/lateral E değerleri anlamlı olarak daha yüksekti. Çoğu doku Doppler parametreleri ile bel çevresi, BKİ-Z skoru, açlık kan şekeri, HOMD, serum insülin düzeyi sistolik ve diyastolik kan basıncı, trigliserid ve YYL-K arasında korelasyon vardı. Bel çevresi ve BKİ-Z skoru bazı doku Doppler parametreleri için belirleyiciydi.Sonuç: Obez çocuklarda akranlarına göre sol ventrikül diyastolik fonksiyonları bozulmuştur. Risk faktörleriyle diyastolik fonksiyon parametreleri arasında korelasyon olsa da, obezitenin kendisi sol ventrikül diyastolik fonksiyonlarında azalmayla ilişkilidir.
Introduction: We aimed to asses two dimensional, M-Mode, conventional and tissue Doppler echocardiographic parameters of left ventricle and to evaluate the effects of antropometric and biochemical factors on these parameters in obese and normal weight children.Patients and Methods: This observational cross-sectional study included 60 obese and 60 nonobese children aged 8-15 years. Echocardiographic parameters of left ventricle were measured in all subjects and investigated the relationship with anthropometric and biochemical factors.Results: Waist circumference, body mass index-Z (BMI-Z) score, systolic and diastolic blood pressure, triglyceride, fasting glucose, insulin concentrations, and homeostatic model assessment (HOMA) index were signifi cantly higher, whereas high density lipoprotein-cholesterol (HDLC) concentration was signifi cantly lower in the obese than in the non-obese group. Mitral annulus septal E' and E'/A', mitral annulus lateral E' and E'/A', anterior E' and E'/A', inferior E' and E'/A' values were signifi cantly lower, whereas mitral E/septal E' and mitral E/lateral E' values were signifi cantly higher in obese than in non-obese subjects. Most of the tissue Doppler parameters were correlated with waist circumference, BMI-Z score, fasting blood glucose, HOMA, systolic and diastolic blood pressure, serum insulin levels, triglyceride and HDL. Waist circumference and BMI-Z score were decisive for some tissue Doppler parameters.Conclusion: Left ventricular diastolic functions are impaired in obese children compared to that of their peers. Although there were correlation between diastolic dysfunction parameters and risk factors, obesity itself is related with reduction of left ventricular diastolic functions.
Introduction: We aimed to asses two dimensional, M-Mode, conventional and tissue Doppler echocardiographic parameters of left ventricle and to evaluate the effects of antropometric and biochemical factors on these parameters in obese and normal weight children.Patients and Methods: This observational cross-sectional study included 60 obese and 60 nonobese children aged 8-15 years. Echocardiographic parameters of left ventricle were measured in all subjects and investigated the relationship with anthropometric and biochemical factors.Results: Waist circumference, body mass index-Z (BMI-Z) score, systolic and diastolic blood pressure, triglyceride, fasting glucose, insulin concentrations, and homeostatic model assessment (HOMA) index were signifi cantly higher, whereas high density lipoprotein-cholesterol (HDLC) concentration was signifi cantly lower in the obese than in the non-obese group. Mitral annulus septal E' and E'/A', mitral annulus lateral E' and E'/A', anterior E' and E'/A', inferior E' and E'/A' values were signifi cantly lower, whereas mitral E/septal E' and mitral E/lateral E' values were signifi cantly higher in obese than in non-obese subjects. Most of the tissue Doppler parameters were correlated with waist circumference, BMI-Z score, fasting blood glucose, HOMA, systolic and diastolic blood pressure, serum insulin levels, triglyceride and HDL. Waist circumference and BMI-Z score were decisive for some tissue Doppler parameters.Conclusion: Left ventricular diastolic functions are impaired in obese children compared to that of their peers. Although there were correlation between diastolic dysfunction parameters and risk factors, obesity itself is related with reduction of left ventricular diastolic functions.
Açıklama
Anahtar Kelimeler
Kalp ve Kalp Damar Sistemi, Endokrinoloji ve Metabolizma, Genel ve Dahili Tıp, Fizyoloji
Kaynak
Koşuyolu Heart Journal
WoS Q Değeri
Scopus Q Değeri
Cilt
16
Sayı
3
