CD4(+), CD25(+), FOXP3(+) T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer/Plenum Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this study. Blood samples collected from children were marked with CD4, CD25, ve Foxp3 in order to detect Tregs and Ths by flow cytometric method. Statistical analyses were performed. p a parts per thousand currency signaEuro parts per thousand 0.05 was chosen as meaningful threshold. Tregs exhibiting anti-inflammatory nature were significantly lower in obese (0.16 %; p a parts per thousand currency signaEuro parts per thousand 0.001), asthmatic (0.25 %; p a parts per thousand currency signaEuro parts per thousand 0.01), and asthmatic obese (0.29 %; p a parts per thousand currency signaEuro parts per thousand 0.05) groups than control group (0.38 %). Ths were counted higher in asthma group than control (p a parts per thousand currency signaEuro parts per thousand 0.01) and obese (p a parts per thousand currency signaEuro parts per thousand 0.001) groups. T cell immunity plays important roles in chronic inflammatory diseases such as obesity and asthma pathogeneses. Decreased numbers of Tregs found in obese, asthmatic, and asthmatic obese children might represent a challenge of these cells.
Açıklama
Anahtar Kelimeler
obesity, asthma, childhood, T regulatory cells, flow cytometry, Peripheral-Blood, Childhood Asthma, Frequency, Treg, Link
Kaynak
Inflammation
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
38
Sayı
4
