CD4(+), CD25(+), FOXP3(+) T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children

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dc.authorid0000-0002-4060-0583
dc.authorid0000-0001-5992-9488
dc.authorid0000-0002-5630-3399
dc.authorscopusid6601976056
dc.authorscopusid55332236300
dc.authorscopusid55332319400
dc.authorscopusid6701664192
dc.authorscopusid37058172000
dc.authorscopusid36165893600
dc.authorscopusid6602805712
dc.authorwosidDonma, Metin/AAB-6079-2020
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.authorwosidDonma, Orkide/AAI-1853-2019
dc.authorwosidDonma, Mustafa Metin/ABF-2169-2021
dc.authorwosidNALBANTOGLU, BURCIN/A-5386-2018
dc.contributor.authorDonma, Mustafa Metin
dc.contributor.authorKarasu, Erkut
dc.contributor.authorÖzdilek, Burcu
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTopçu, Birol
dc.contributor.authorNalbanto?lu, Burçin
dc.contributor.authorDonma, Orkide
dc.date.accessioned2022-05-11T14:10:10Z
dc.date.available2022-05-11T14:10:10Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.description.abstractThe aim of this prospective case control study is to determine CD4(+), CD25(+), and FoxP3(+) T regulatory cells (Tregs) and T helper cells (Ths) in obese, asthmatic, asthmatic obese, and healthy children. Obese (n = 40), asthmatic (n = 40), asthmatic obese (n = 40), and healthy children (n = 40) were included in this study. Blood samples collected from children were marked with CD4, CD25, ve Foxp3 in order to detect Tregs and Ths by flow cytometric method. Statistical analyses were performed. p a parts per thousand currency signaEuro parts per thousand 0.05 was chosen as meaningful threshold. Tregs exhibiting anti-inflammatory nature were significantly lower in obese (0.16 %; p a parts per thousand currency signaEuro parts per thousand 0.001), asthmatic (0.25 %; p a parts per thousand currency signaEuro parts per thousand 0.01), and asthmatic obese (0.29 %; p a parts per thousand currency signaEuro parts per thousand 0.05) groups than control group (0.38 %). Ths were counted higher in asthma group than control (p a parts per thousand currency signaEuro parts per thousand 0.01) and obese (p a parts per thousand currency signaEuro parts per thousand 0.001) groups. T cell immunity plays important roles in chronic inflammatory diseases such as obesity and asthma pathogeneses. Decreased numbers of Tregs found in obese, asthmatic, and asthmatic obese children might represent a challenge of these cells.
dc.description.sponsorshipNamik Kemal University Scientific Research Projects Coordination UnitNamik Kemal University
dc.description.sponsorshipThis study was supported by Namik Kemal University Scientific Research Projects Coordination Unit. BAP protocol no: NKUBAP.00.20.AR.12.09/01.06.2012.
dc.identifier.doi10.1007/s10753-015-0122-4
dc.identifier.endpage1478
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue4en_US
dc.identifier.pmid25655390
dc.identifier.scopus2-s2.0-84937251492
dc.identifier.scopusqualityQ2
dc.identifier.startpage1473
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0122-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5313
dc.identifier.volume38
dc.identifier.wosWOS:000357666000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDonma, Mustafa Metin
dc.institutionauthorÖzdilek, Burcu
dc.institutionauthorTurgut, Burhan
dc.institutionauthorTopçu, Birol
dc.institutionauthorNalbanto?lu, Burçin
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectobesity
dc.subjectasthma
dc.subjectchildhood
dc.subjectT regulatory cells
dc.subjectflow cytometry
dc.subjectPeripheral-Blood
dc.subjectChildhood Asthma
dc.subjectFrequency
dc.subjectTreg
dc.subjectLink
dc.titleCD4(+), CD25(+), FOXP3(+) T Regulatory Cell Levels in Obese, Asthmatic, Asthmatic Obese, and Healthy Children
dc.typeArticle

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