Astma ve alerjik rinitli çocuklarda total IgE, C-reaktif protein ve kan sayım parametrelerinin değerlendirilmesi
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Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmanın amacı; astım ve alerjik rinit tanısı alan çocukların total IgE, C reaktif protein (CRP) ve tamkan sayım parametrelerinin hastalık ile ilişkilerinin olup olmadığını retrospektif olarak araştırmaktır.Gereç ve Yöntem: Hastanemiz Çocuk Sağlığı ve Has- talıkları polikliniğine gelen 2-18 yaş arası toplam 443 ço- cuğun retrospektif taraması yapıldı. Muayene sonuçları- na göre çocuklar astım (n=179), alerjik rinit (n=171) ve kontrol grubu (n=93) olarak üçe ayrıldı. Her gruptaki ço- cukların serum total IgE ve CRP düzeyleri ile hemogram değerleri, yaş ve cinsiyetleri kaydedildi. Bulgular: Astım grubunda eozinofil sayısı, MCHC ve total IgE düzeyleri kontrol grubuna göre anlamlı olarak artar- ken, MCV düzeyi azalmıştır. Alerjik rinit grubunda lenfosit sayısı, CRP ve total IgE düzeyleri kontrol grubuna göre anlamlı olarak artarken nötrofil sayısı azalmış, eozinofil sayısında ise anlamlı bir değişiklik gözlenmemiştir. Sonuçlar: Bu sonuçlar; astım patagonezinde etkili olan faktörlerin eritrosit morfolojisi üzerine de etkili olduğunu düşündürmektedir. Ayrıca, astımda kan eozinofil düzeyin- deki değişiklikler, alerjik rinitte ise nötrofil ve lenfosit düze- yindeki değişikler dikkat çekmekte olup, astımda serum total IgE düzeylerinde, alerjik rinitte ise CRP düzeylerinde artış saptanmıştır.
Objective: This study aimed to research retrospectively whether asthma and allergic rhinitis are related to total IgE, C-reactive protein (CRP) and complete blood count parameters.Materials and methods: Files of 443 children who ap- plied to pediatric outpatient clinics of our hospital,aged 2-18 were retrospectively investigated. Patients were grouped into three as asthma (n=179), allergic rhinitis (n= 171) and control group (n= 93). Patients’ ages, genders, total IgE, CRP and hemogram values were recorded. Results: While eosinophil count, MCHC and total IgE levels were significantly higher in asthma group, MCV levels were significantly lower. Lymphocyte count, CRP and total IgE levels were significantly higher in allergic rhinitis group compared with control group whereas neu- trophil count were significantly lower and eosinophil count did not change significantly. Total IgE levels were higher in asthma and allergic rhinitis compared with controls. However, CRP levels were higher only in allergic rhini- tis group. MCV levels were significantly lower in asthma group compared with controls. MCHC levels were sig- nificantly higher in asthma group compared with allergic rhinitis and control groups. Neutrophil count decreased while lymphocyte count increased significantly. Eosino- phil count significantly increased compared with control group whereas a significant difference was not observed between allergic rhinitis and controls. Conclusions: Our findings suggest factors effective in asthma pathogenesis might be effective also in erythro- cyte morphology. There are remarkable changes in blood eosinophil levels in asthma and in neuthrophil and lym- phocyte levels in allergic rhinitis. Serum total IgE level in- creases in asthma group whereas it decreases in allergic rhinitis group.
Objective: This study aimed to research retrospectively whether asthma and allergic rhinitis are related to total IgE, C-reactive protein (CRP) and complete blood count parameters.Materials and methods: Files of 443 children who ap- plied to pediatric outpatient clinics of our hospital,aged 2-18 were retrospectively investigated. Patients were grouped into three as asthma (n=179), allergic rhinitis (n= 171) and control group (n= 93). Patients’ ages, genders, total IgE, CRP and hemogram values were recorded. Results: While eosinophil count, MCHC and total IgE levels were significantly higher in asthma group, MCV levels were significantly lower. Lymphocyte count, CRP and total IgE levels were significantly higher in allergic rhinitis group compared with control group whereas neu- trophil count were significantly lower and eosinophil count did not change significantly. Total IgE levels were higher in asthma and allergic rhinitis compared with controls. However, CRP levels were higher only in allergic rhini- tis group. MCV levels were significantly lower in asthma group compared with controls. MCHC levels were sig- nificantly higher in asthma group compared with allergic rhinitis and control groups. Neutrophil count decreased while lymphocyte count increased significantly. Eosino- phil count significantly increased compared with control group whereas a significant difference was not observed between allergic rhinitis and controls. Conclusions: Our findings suggest factors effective in asthma pathogenesis might be effective also in erythro- cyte morphology. There are remarkable changes in blood eosinophil levels in asthma and in neuthrophil and lym- phocyte levels in allergic rhinitis. Serum total IgE level in- creases in asthma group whereas it decreases in allergic rhinitis group.
Açıklama
Anahtar Kelimeler
Alerji, Genel ve Dahili Tıp, Pediatri
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
40
Sayı
1
