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Öğe Bir Simental İnekte Rektal Fibromatozis(2018) Özyiğit, M.Özgür; Nak, Yavuz; İnan, Sevda; Yavaş, ÖzkanBu olayda 4 yaşlı Simental ırkı inekte rektum bölgesinde gözlenen çok sayıdaki tümöral kitlelerden dolayı rektal muayeneyi zorlaştıran ve operasyonuna karar verilen fibromatozis olgusunun klinik ve patolojik yönden incelenmesi amaçlandı. Hayvanda doğumu izleyen dönemde rektal muayene yapılmak istendiğinde rektum çevresinde zamanla sayı ve hacimleri artan kitleler gözlendi. En büyüğü 6,5 cm çapında yuvarlak ve 4x3x1,4cm büyüklüğünde oval, çeşitli büyüklükte 14 adet katı esnek kıvamda, beyaz renkli kitlelere rastlandı. Kitlelerin bazıları deri ve çoğunlukla mukoza ile kaplı olduğu dikkati çekti. %10’luk tamponlu formaldehit ile tespit edilerek parafine gömülen ve 5 µm kalınlığında kesitler alınan dokular, Hematoksilen-Eosin (H-E) ve Van Gieson ile ayrıca immunohistokimyasal (İHK) olarak sitokeratin ve vimentin ile boyandı. H-E kesitli dokulardaki tümöral kitlenin tipik anafor tarzında yerleşmiş fibroblast ve fibrositlerden oluştuğu, yapılan İHK boyamada ise vimentin pozitif ve sitokeratin negatif olarak gözlendi. Bu olgudaki gözlenen makroskobik, mikroskobik ve İHK’sal bulgular kaudal rektumda fibromatozis olgusu ile uyumlu bulunmuşturÖğe Can fracture healing be accelerated by serum transfer in head trauma cases? An experimental head trauma model in rats(Turkish Joint Diseases Foundation, 2021) Sarı, Abdulkadir; Dinçel, Yaşar Mahsut; Çetin, Mehmet Ümit; İnan, SevdaObjectives: In this study, we aimed to investigate whether the positive union effect caused by head trauma could be transferred between individuals.& nbsp; Materials and methods: Seventy-two male rats with an average weight of 375 g were used in this study and divided into four groups including 18 in each group. Group 1 consisted of serum donor rats that were exposed to head trauma, while Group 2 consisted of study rats with long bone fractures that were given the serum obtained from the rats in Group 1, Group 3 included control rats with isolated long bone fractures, and Group 4 included control rats with both head trauma and long bone fractures. For radiological evaluation, the ratio of the width of the callus to the width of the neighboring diaphysis was considered as the callus-todiaphyseal ratio in the study and control groups. Histopathological and radiological evaluations was made on Days 10, 20, and 30.& nbsp; Results: In evaluation of the radiological data regarding the callusto-diaphyseal ratio, Group 3 was found to have significantly lower radiological values than Group 4 on Day 10 (p=0.006). Group 2 had significantly higher values than Group 3 (p=0.02). On Day 20, Group 2 exhibited significantly higher radiological values than Group 3 (p=0.004), but lower than Group 4 (p=0.032). As for Day 30, Group 2 exhibited significantly higher radiological values than Group 3, but lower than Group 4 (p=0.001). In the evaluation of the Huo scores obtained for histopathological evaluation, there was no significant difference among the groups on Days 10, 20, and 30 (p=0.295, p=0.569, and p=0.729, respectively).& nbsp; Conclusion: Our study results suggest that the osteoinductive effect after head trauma can be transmitted between individuals by means of serum transfer.Öğe Dose dependent effects of Spirulina platensis on liver health in rats(Agricultural Research Communication Centre, 2020) Seyidoğlu, Nilay; İnan, Sevda; Güneş, NazmiyeSpirulina platensis which is an important microalgae is interested in both human and animal nutrition for health balance. This study's aimed to evaluate the dose dependent effects of S.platensis on body weight, height, waist circumference (WC), body mass index (BMI), waist/height ratio (WHtR), abdominal fat weight, liver weight, serum liver enzymes and liver histopathology. 30 male Wistar albino rats're used in groups; Control, SP-1(500mg/kgbw) and SP-2(1000mg/kgbw). S.platensis was administered by oral gavage daily. The body weight, height, WC, BMI, WHtR and abdominal lipid weight were calculated. Also, serum cholesterol, ALT and AST were measured. End of the study, liver tissue samples were taken and scaled and histopathologic changes were recorded. There were no differences in body conditions, but positively significant correlations were found among parameters. As the doses were considered, in groupSP-1, significant positively correlations were determined among abdominal fat, growth, height, BMI and WC statistically. Nevertheless, there were no significant changes in liver weight, serum and histopathologic analyzes. S.platensis with its high concentration of functional nutrients is called as an important alternative therapeutic food and it can be used safely. © 2020 Agricultural Research Communication Centre. All rights reserved.Öğe Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats(Routledge, 2021) Özcan Sınır, Gülşah; İnan, Sevda; Suna, Senem; Tamer, Canan Ece; Akgül, Mustafa Barış; Bağdaş, Deniz; Çopur, Ömer UtkuIncreased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals with ad libitum access to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats. © 2020 Taylor & Francis Group, LLC.Öğe İn Vitro Gaz Üretim Tekniği Kullanılarak Yer bademi (Cyperus esculentus) Çeşitlerinin Besin Değerinin Saptanması(2021) Ayaşan, Tugay; İnci, Hakan; Hızlı, Hatice; İnan, Sevda; Ülger, İsmail; Sucu, EkinBu çalışmada, farklı yer bademi çeşitlerinin (Sarı şeker, İntrodüksiyon 1, Bal yumru) besin madde değerlerinin ve koçlarda sindirilebilirliklerinin belirlenmesi amaçlanmıştır. Farklı yer bademi çeşitlerinin ortalama gaz üretimi, 96 saatlik inkübasyondan sonra in vitro gaz üretim kinetiği ve in vitro inkübasyon süreleri belirlenmiştir. Yetiştirilen farklı yer bademi çeşitlerinin in vitro gaz üretim tekniği kullanılarak a, b, c, a + b'nin pearson korelasyon katsayıları ve pearson korelasyon katsayıları bulunmuştur. Çalışmada farklı yer bademi çeşitlerinin değişik zamanlardaki ortalama gaz üretimleri sadece 3. saatte önemli bulunmuş; 96 saatlik inkübasyondan sonraki in vitro gaz üretim kinetikleri, çeşitler arasında farklılık yaratmamış; in vitro inkübasyon zamanları ile pearson korelasyon katsayıları arasındaki ilişki önemli tespit edilmiştir. Yer bademi çeşitlerinin ortalama ham proteini (HP) %4.39; kuru maddesi (KM) %94.08; ham yağı (HY) %24.85; ham külü (HK) %2.53; asit deterjanda çözünmeyen lif (ADF) %15.04, nötr deterjanda çözünmeyen lif (NDF) %24.03; lif olmayan karbonhidrat (LOK) %44.20 olarak bulunmuştur. Yer bademi çeşitlerinin ortalama toplam sindirilebilir besin maddesi %72.78; metabolik enerjisi 2.63 Mcal/kg KM, sindirilebilir enerjisi 3.21 Mcal/kg KM ve de net enerji laktasyon değeri 1.66 Mcal/kg KM olarak tespit edilmiştir.Öğe Organic and Ecological Production of Chicken Meat and Eggs: A Review of the Regulatory Harmonization Between the EU and Republic of Serbia(2022) Milojevi?, Milena; Miloševi?, Aleksandra; Ayaşan, Tugay; Zari?, Sladjana; İnan, SevdaThe interest in organic livestock and products produced from animals has increased considerably in recent years; Studies on this subject have been concentrated. In this review, organic and ecological production of chicken meat and eggs has been examined: the review of legislative harmony between the EU and the Republic of Serbia. Pure (autochthonous) breeds and their crossbreeds in organic production have lately become the research subject of a growing number of authors. Basic principles of organic livestock production, among other things, refer to domestic animals welfare which inherently includes their health preservation and the production of high quality animal products with the aim of setting up and organizing ecologically acceptable production. Organic products are tasty, helth safe and have high nutritive values.Öğe The relationship between Spirulina platensis and selected biomechanical indicators of tibiae in rats(Czech Academy of Agricultural Sciences, 2020) Süzer, Bayram; Seyidoğlu, Nilay; Tüfekci, Kenan; İnan, SevdaThere are several dietary supplements, particularly herbal foods, that have been used in an attempt to improve bone growth. In this study, we aim at determining the effects of low- and high-doses of Spirulina platensis, a “Superfood”, on the bone growth and biomechanical indicators. Thirty Wistar rats, weighing 250 g, at the age of 7–8 weeks were assigned to three groups: The Control group (basal diet), Low-dose group (LDG; 500 mg/kg) and High-dose group (HDG; 1 000 mg/kg) of S. platensis. S. platensis was given daily by oral gavage in a 45-day-trial. At the end of the study, the right tibiae were collected and subjected to bone biomechanical tests (bone weight, bone length, maximum load, stiffness, breaking deflection, fracture toughness, post-yield displacement and yield load). Serum samples were also analysed for the calcium and phosphorus concentrations. There were significant increases in bone weight, bone length, maximum load, breaking deflection, work to fracture, post-yield displacement and yield load (P = 0.025, P = 0.019, P = 0.030, P = 0.015, P = 0.031, P = 0.028, P = 0.049, respectively), whereas stiffness non-significantly increased. However, there were no significant differences (P > 0.05) for any variables between the LDG and the HDG. Although the serum phosphorus concentrations showed no differences among any of the groups, the serum calcium concentration increased significantly in LDG compared to Control group (P=0.009; 7.14 ± 0.47 and 9.45 ± 0.67, respectively). However, no differences were observed in HDG in terms of serum calcium. In conclusion, S. platensis had positive effects on the bone growth and biomechanical bone features. Therefore, our study supports the use of S. platensis as an alternative food additive for bone growth and health in growing animals. © 2020 Czech Academy of Agricultural Sciences. All rights reserved.
