Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Routledge
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Increased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals with ad libitum access to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats. © 2020 Taylor & Francis Group, LLC.
Açıklama
Anahtar Kelimeler
7,12 dimethylbenz[a]anthracene, corn syrup, glucose, sucrose, 7,12 dimethylbenz[a]anthracene, fructose, animal experiment, animal model, animal tissue, Article, autopsy, body weight, cancer morphology, carcinogenesis, chow diet, clinical evaluation, comparative study, controlled study, data analysis software, food intake, fructose intake, glucose blood level, histopathology, male, nectar, nonhuman, pancreas adenocarcinoma, peach, rat, sham procedure, Sprague Dawley rat, tumor differentiation, animal, maize, pancreas carcinoma, pancreas tumor, 9,10-Dimethyl-1,2-benzanthracene, Animals, Carcinoma, Pancreatic Ductal, Fructose, High Fructose Corn Syrup, Male, Pancreatic Neoplasms, Rats, Rats, Sprague-Dawley, Zea mays
Kaynak
Nutrition and Cancer
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
73
Sayı
2
