Effect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats

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dc.authorscopusid57194441710
dc.authorscopusid56320836200
dc.authorscopusid55512747500
dc.authorscopusid8228159500
dc.authorscopusid57200004413
dc.authorscopusid15062425700
dc.authorscopusid55167435000
dc.contributor.authorÖzcan Sınır, Gülşah
dc.contributor.authorİnan, Sevda
dc.contributor.authorSuna, Senem
dc.contributor.authorTamer, Canan Ece
dc.contributor.authorAkgül, Mustafa Barış
dc.contributor.authorBağdaş, Deniz
dc.contributor.authorÇopur, Ömer Utku
dc.date.accessioned2022-05-11T14:05:15Z
dc.date.available2022-05-11T14:05:15Z
dc.date.issued2021
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümü, Patoloji Ana Bilim Dalı
dc.description.abstractIncreased risk of pancreatic cancer may be associated with consumption of sugar containing foods. The aim of this study was to evaluate the effect of peach nectar containing high fructose corn sirup (HFCS) consumption in a pancreatic carcinogenesis rat model induced by 7,12-Dimethyl benzanthracene (DMBA). Fifty-day-old male Sprague Dawley rats were fed with peach nectar containing HFCS + chow, peach nectar containing sucrose + chow and only chow. After 8 mo, feeding period, each group was divided into two subgroups, in which the rats were implanted with DMBA and no DMBA (sham). Histologic specimens were evaluated according to the routine tissue processing protocol. The animals with ad libitum access to pn-HFCS, pn-sucrose and chow (only) showed significant differences in chow consumption and glucose level. Necropsy and histopathologic findings showed tumor formation in the entire group treated with DMBA. Excluding one rat in chow group, which was classified as poorly differentiated type, the others were classified as moderately differentiated pancreatic ductal adenocarcinoma (PDAC). This study demonstrated that daily intake of HFCS did not increase body weight and there was no effect of peach nectar consumption on the development of PDAC induced by DMBA in rats. © 2020 Taylor & Francis Group, LLC.
dc.description.sponsorship2011/65
dc.description.sponsorshipThis research was supported by Bursa Uludag University Scientific Research Project No: UAP(Z) 2011/65. GOS, SI, SS, MBA, DB, HZD, DS and BI collected and interpreted data, drafted article and approved the final version. CET, GS, TE, EK, ES, OFT, IE, OUC designed the study, critically revised article and approved the final version.
dc.identifier.doi10.1080/01635581.2020.1770811
dc.identifier.endpage349
dc.identifier.issn0163-5581
dc.identifier.issue2en_US
dc.identifier.pmid32475178
dc.identifier.scopus2-s2.0-85086577033
dc.identifier.scopusqualityQ2
dc.identifier.startpage339
dc.identifier.urihttps://doi.org/10.1080/01635581.2020.1770811
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4932
dc.identifier.volume73
dc.identifier.wosWOS:000542464600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorİnan, Sevda
dc.language.isoen
dc.publisherRoutledge
dc.relation.ispartofNutrition and Cancer
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subject7,12 dimethylbenz[a]anthracene
dc.subjectcorn syrup
dc.subjectglucose
dc.subjectsucrose
dc.subject7,12 dimethylbenz[a]anthracene
dc.subjectfructose
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectautopsy
dc.subjectbody weight
dc.subjectcancer morphology
dc.subjectcarcinogenesis
dc.subjectchow diet
dc.subjectclinical evaluation
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdata analysis software
dc.subjectfood intake
dc.subjectfructose intake
dc.subjectglucose blood level
dc.subjecthistopathology
dc.subjectmale
dc.subjectnectar
dc.subjectnonhuman
dc.subjectpancreas adenocarcinoma
dc.subjectpeach
dc.subjectrat
dc.subjectsham procedure
dc.subjectSprague Dawley rat
dc.subjecttumor differentiation
dc.subjectanimal
dc.subjectmaize
dc.subjectpancreas carcinoma
dc.subjectpancreas tumor
dc.subject9,10-Dimethyl-1,2-benzanthracene
dc.subjectAnimals
dc.subjectCarcinoma, Pancreatic Ductal
dc.subjectFructose
dc.subjectHigh Fructose Corn Syrup
dc.subjectMale
dc.subjectPancreatic Neoplasms
dc.subjectRats
dc.subjectRats, Sprague-Dawley
dc.subjectZea mays
dc.titleEffect of High Fructose Corn Sirup on Pancreatic Ductal Adenocarcinoma Induced by Dimethyl Benzantracene (DMBA) in Rats
dc.typeArticle

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