Can fracture healing be accelerated by serum transfer in head trauma cases? An experimental head trauma model in rats
Yükleniyor...
Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Joint Diseases Foundation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: In this study, we aimed to investigate whether the positive union effect caused by head trauma could be transferred between individuals.& nbsp; Materials and methods: Seventy-two male rats with an average weight of 375 g were used in this study and divided into four groups including 18 in each group. Group 1 consisted of serum donor rats that were exposed to head trauma, while Group 2 consisted of study rats with long bone fractures that were given the serum obtained from the rats in Group 1, Group 3 included control rats with isolated long bone fractures, and Group 4 included control rats with both head trauma and long bone fractures. For radiological evaluation, the ratio of the width of the callus to the width of the neighboring diaphysis was considered as the callus-todiaphyseal ratio in the study and control groups. Histopathological and radiological evaluations was made on Days 10, 20, and 30.& nbsp; Results: In evaluation of the radiological data regarding the callusto-diaphyseal ratio, Group 3 was found to have significantly lower radiological values than Group 4 on Day 10 (p=0.006). Group 2 had significantly higher values than Group 3 (p=0.02). On Day 20, Group 2 exhibited significantly higher radiological values than Group 3 (p=0.004), but lower than Group 4 (p=0.032). As for Day 30, Group 2 exhibited significantly higher radiological values than Group 3, but lower than Group 4 (p=0.001). In the evaluation of the Huo scores obtained for histopathological evaluation, there was no significant difference among the groups on Days 10, 20, and 30 (p=0.295, p=0.569, and p=0.729, respectively).& nbsp; Conclusion: Our study results suggest that the osteoinductive effect after head trauma can be transmitted between individuals by means of serum transfer.
Açıklama
Anahtar Kelimeler
Fracture healing, histopathology, rat, serum transfer, traumatic brain injury, Brain-Injury
Kaynak
Joint Diseases and Related Surgery
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
32
Sayı
2
