Can fracture healing be accelerated by serum transfer in head trauma cases? An experimental head trauma model in rats

dc.authorid0000-0003-3416-5666
dc.authorid0000-0001-6576-1802
dc.authorid0000-0001-9827-8892
dc.authorid0000-0001-8138-5851
dc.authorscopusid57196712908
dc.authorscopusid55994580900
dc.authorscopusid57208565301
dc.authorscopusid56320836200
dc.authorwosidçetin, mehmet ümit/AAA-4905-2022
dc.authorwosidsari, abdulkadir/AAF-3143-2021
dc.authorwosidINAN, SEVDA/E-3364-2018
dc.authorwosidsari, abdulkadir/ABH-3293-2021
dc.contributor.authorSarı, Abdulkadir
dc.contributor.authorDinçel, Yaşar Mahsut
dc.contributor.authorÇetin, Mehmet Ümit
dc.contributor.authorİnan, Sevda
dc.date.accessioned2022-05-11T14:12:30Z
dc.date.available2022-05-11T14:12:30Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractObjectives: In this study, we aimed to investigate whether the positive union effect caused by head trauma could be transferred between individuals.& nbsp; Materials and methods: Seventy-two male rats with an average weight of 375 g were used in this study and divided into four groups including 18 in each group. Group 1 consisted of serum donor rats that were exposed to head trauma, while Group 2 consisted of study rats with long bone fractures that were given the serum obtained from the rats in Group 1, Group 3 included control rats with isolated long bone fractures, and Group 4 included control rats with both head trauma and long bone fractures. For radiological evaluation, the ratio of the width of the callus to the width of the neighboring diaphysis was considered as the callus-todiaphyseal ratio in the study and control groups. Histopathological and radiological evaluations was made on Days 10, 20, and 30.& nbsp; Results: In evaluation of the radiological data regarding the callusto-diaphyseal ratio, Group 3 was found to have significantly lower radiological values than Group 4 on Day 10 (p=0.006). Group 2 had significantly higher values than Group 3 (p=0.02). On Day 20, Group 2 exhibited significantly higher radiological values than Group 3 (p=0.004), but lower than Group 4 (p=0.032). As for Day 30, Group 2 exhibited significantly higher radiological values than Group 3, but lower than Group 4 (p=0.001). In the evaluation of the Huo scores obtained for histopathological evaluation, there was no significant difference among the groups on Days 10, 20, and 30 (p=0.295, p=0.569, and p=0.729, respectively).& nbsp; Conclusion: Our study results suggest that the osteoinductive effect after head trauma can be transmitted between individuals by means of serum transfer.
dc.identifier.doi10.52312/jdrs.2021.8
dc.identifier.endpage312
dc.identifier.issn2687-4784
dc.identifier.issn2687-4792
dc.identifier.issue2en_US
dc.identifier.pmid34145805
dc.identifier.scopus2-s2.0-85108553209
dc.identifier.scopusqualityQ2
dc.identifier.startpage306
dc.identifier.urihttps://doi.org/10.52312/jdrs.2021.8
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5582
dc.identifier.volume32
dc.identifier.wosWOS:000661415100005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSarı, Abdulkadir
dc.institutionauthorDinçel, Yaşar Mahsut
dc.institutionauthorÇetin, Mehmet Ümit
dc.institutionauthorİnan, Sevda
dc.language.isoen
dc.publisherTurkish Joint Diseases Foundation
dc.relation.ispartofJoint Diseases and Related Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFracture healing
dc.subjecthistopathology
dc.subjectrat
dc.subjectserum transfer
dc.subjecttraumatic brain injury
dc.subjectBrain-Injury
dc.titleCan fracture healing be accelerated by serum transfer in head trauma cases? An experimental head trauma model in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Yükleniyor...
Küçük Resim
İsim:
5582.pdf
Boyut:
824.42 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text