Immunohistochemical examination on the effects of malathion and Onosma nigricaule (Boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in renal tissues of mice

Basit Öğe Kaydı
dc.authorid0000-0002-5703-2164
dc.authorscopusid37121662100
dc.authorscopusid25649278000
dc.authorscopusid34971025700
dc.authorscopusid27667663200
dc.authorscopusid57188626782
dc.authorscopusid6701361197
dc.authorwosidAsker, Hasan/A-5543-2018
dc.authorwosidbakır, buket/ABA-8248-2020
dc.contributor.authorBakır, Buket
dc.contributor.authorErdag, Dinçer
dc.contributor.authorEliş Yıldız, Sevda
dc.contributor.authorKaradağ Sarı, Ebru
dc.contributor.authorAsker, Hasan
dc.contributor.authorSozmen, Mahmut
dc.date.accessioned2022-05-11T14:42:28Z
dc.date.available2022-05-11T14:42:28Z
dc.date.issued2017
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe purpose of this study was to determine the effects of the plant extract, which is obtained from Onosma nigricaule due to the oxidation parameters caused in mice by malathion that is used as an insecticide in agriculture, on catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in kidney tissues by immunohistochemical technique. A total of 48 male mice (Mus musculus) were used in our study. Mice were divided 6 groups (control group, maize oil group, normal saline group, Onosma nigricaule group, malathion group, Onosma nigrcaule+malathion group). Hematoxylin-eosin and triple staining methods were used for histological and pathological examinations. The localization of CAT and Mn-SOD in the renal tissue was determined using the method of streptavidinbiotin- peroxidase. CAT immunoreactivity was determined with a weak intensity in epithelium of renal tubulus proximalis of mice in the malathion group, with a moderate intensity in Onosma nigricaule+ malathion group and with a higher intensity in tubulus proximalis of other groups. A cytoplasmic Mn-SOD immunoreactivity was determined with weak intensity in renal medulla of mice in malathion group, with moderate intensity in renal medulla of mice in Onosma nigricaule plant extract+ malathion group, maize oil group, and normal saline group and with highly intensity in control and Onosma nigricaule groups. It was concluded that Onosma nigricaule might play a protective role as an antioxidant against the oxidant features of malathion.
dc.description.sponsorshipKafkas University, BAPKafkas University [2013-KSYO-78]
dc.description.sponsorshipThis research was supported by a grant from the Kafkas University, BAP (Project No: 2013-KSYO-78.
dc.identifier.endpage130
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85013466897
dc.identifier.scopusqualityQ3
dc.identifier.startpage125
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9386
dc.identifier.volume64
dc.identifier.wosWOS:000398845100009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBakır, Buket
dc.language.isoen
dc.publisherAnkara Univ Press
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCatalase
dc.subjectkidney
dc.subjectmalathion
dc.subjectmice
dc.subjectOnosma nigricaule
dc.subjectsuperoxide dismutase
dc.subjectOxidative Stress
dc.subjectFree-Radicals
dc.subjectRats
dc.subjectLiver
dc.subjectLocalization
dc.subjectEnzymes
dc.titleImmunohistochemical examination on the effects of malathion and Onosma nigricaule (Boraginaceae) on the catalase (CAT) and superoxide dismutase-2 (Mn-SOD) in renal tissues of mice
dc.title.alternativeMalathion ve Onosma nigricaule (Boraginaceae)'nin fare böbrek dokusunda katalaz (CAT) ve süperoksit dismutaz-2 (Mn-SOD) salınımı üzerine etkileri]
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
9386.pdf
Boyut:
693.25 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu
Veteriner Fakültesi Koleksiyonu