The relationship between the levels of the fluoride ion and the thyroid hormones in goats with fluorosis
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Date
2017
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
International Society for Fluoride Research
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
In the present study, 104 goats with endemic fluorosis, living at the foot of the mountains Ağrı (Mount Ararat) and Tendürek, were compared with 30 healthy goats to investigate the relationship between the plasma levels of the fluoride ion (F) and the thyroid hormones. In addition to the 104 goats with fluorosis all having dental fluorosis, 1.92% had exostoses in their palpable bones, 19.23% had mastication difficulties with weight loss, 2.88% had nail deformities, and 7.69% had lameness. However, signs of goitre in their necks were not present on inspection and palpation. The plasma F concentration was significantly higher (p<0.001) in the fluorosis group compared to the control group. The plasma F concentrations tended to be higher in the older animals compared to the younger animals, but not significantly so. Compared to the control group, the serum total thyroxine (TT4) was significantly reduced (p<0.01) in the fluorosis group. No significant differences between the fluorosis and the control groups were found for the serum concentrations of total triiodotyronine (TT3), free triiodotyronine (FT3), or free thyroxine (FT4). Significant decreases were present in the levels of TT3(p<0.01) and FT4(p<0.001) in the older goats with fluorosis, 3–5-years-old and >5-years-old, compared to the younger animals, aged 1–<3 years. © 2017, ISFR.
Description
Keywords
Fluoride, Fluorosis, Goats, Goitre, Thyroid hormones, fluoride ion, thyroid hormone, thyronine, thyroxine, animal experiment, animal lameness, Article, child, controlled study, fluorosis, goat, mastication, nail disease, nonhuman, thyroxine blood level, weight reduction
Journal or Series
Fluoride
WoS Q Value
Scopus Q Value
Q3
Volume
50
Issue
1
