Development and validation of a sensitive spectrofluorimetric method for the determination of amoxapine in human plasma and urine

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dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorscopusid34574169900
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorUlu, Sevgi Tatar
dc.date.accessioned2022-05-11T14:29:53Z
dc.date.available2022-05-11T14:29:53Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA selective and sensitive spectrofluorimetric method was developed and validated for the determination of amoxapine in human plasma and urine. The developed method is based on labeling with 5-dimethylaminonaphthalene-1-sulfonyl chloride (dansyl chloride) and monitoring at 397nm (excitation)/514nm (emission). The method was validated for linearity, limit of detection (LOD), limit of quantification (LOQ), precision, accuracy, recovery and robustness. The calibration curves were linear over a concentration range of 250-2500 and 50-1250ng/mL for plasma and urine, respectively. The LOD values were calculated to be 13.31 and 13.17ng/mL for plasma and urine, respectively. The proposed method was applied to study of amoxapine in human plasma and urine. Copyright (c) 2013 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/bio.2541
dc.identifier.endpage287
dc.identifier.issn1522-7235
dc.identifier.issn1522-7243
dc.identifier.issue3en_US
dc.identifier.pmid23780763
dc.identifier.scopus2-s2.0-84898785782
dc.identifier.scopusqualityQ2
dc.identifier.startpage284
dc.identifier.urihttps://doi.org/10.1002/bio.2541
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7166
dc.identifier.volume29
dc.identifier.wosWOS:000334346000013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofLuminescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectderivatization
dc.subjectspectrofluorimetry
dc.subjectplasma
dc.subjecturine
dc.subjectvalidation
dc.subjectdansyl chloride
dc.subjectPerformance Liquid-Chromatography
dc.subjectTricyclic Antidepressants
dc.subjectWhole-Blood
dc.subjectMetabolites
dc.subjectChloride
dc.subjectSerum
dc.titleDevelopment and validation of a sensitive spectrofluorimetric method for the determination of amoxapine in human plasma and urine
dc.typeArticle

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