Development and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study

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dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorscopusid57194079040
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorÖzdemir, Elif
dc.date.accessioned2022-05-11T14:31:01Z
dc.date.available2022-05-11T14:31:01Z
dc.date.issued2019
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractZero and first order derivative spectrophotometric methods were developed for the analysis of rilmenidine in pharmaceutical preparations. Absorbances of rilmenidine were measured at 224 rim for the zero order by measuring height of peak from zero and at 223.20 and 230.20 nm for the first order derivative spectrophotometric method by measuring peak to peak height. The linearity ranges were found to be 50-250 mu g/mL for zero and first order spectrophotometric method. The developed methods were validated and the analytical parameters of linearity, limit of detection, limit of quantification, accuracy, precision and recovery were evaluated. In addition, Rilmenidine exposed to the stress conditions of acid, base and oxidative in order to calculate to degradation % by developed zero and first order derivative spectrophotometric method.
dc.description.sponsorshipResearch Fund of the University of Namik Kemal [NKUBAP.00, 16.026]
dc.description.sponsorshipThis work was supported by the Research Fund of the University of Namik Kemal (Project no: NKUBAP.00.GA.16.026).
dc.identifier.doi10.12991/jrp.2019.152
dc.identifier.endpage464
dc.identifier.issn2630-6344
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85066972754
dc.identifier.scopusqualityQ3
dc.identifier.startpage457
dc.identifier.urihttps://doi.org/10.12991/jrp.2019.152
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7279
dc.identifier.volume23
dc.identifier.wosWOS:000468157000011
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherMarmara Univ
dc.relation.ispartofJournal of Research in Pharmacy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectRilmenidine
dc.subjectderivative spectrophotometric method
dc.subjectforced degradation study
dc.subjectvalidation
dc.subjectBlood-Pressure
dc.subjectHypertension
dc.subjectLosartan
dc.subjectDisease
dc.subjectBurden
dc.subjectStroke
dc.subjectRisk
dc.titleDevelopment and validation of first and zero order derivative spectrophotometric methods for the determination of rilmenidine in pharmaceutical preparations and forced degradation study
dc.typeArticle

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