Spectrofluorimetric determination of nateglinide in pure and pharmaceutical preparations through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole

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dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorscopusid34574169900
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorUlu, Sevgi Tatar
dc.date.accessioned2022-05-11T14:29:56Z
dc.date.available2022-05-11T14:29:56Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA sensitive method was developed for the determination of nateglinide in pure and pharmaceutical preparations. The proposed method is based on the derivatization reaction between nateglinide and 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole in borate buffer of pH 10. Fluorescent intensity of derivative was measured at 537 nm using an excitation wavelength of 464 nm. The described method was validated and the analytical parameters of linearity, limit of detection, limit of quantification, accuracy, precision (intra- and inter-day) and recovery were evaluated. The assay was linear over the concentration range of 50-500 ng/mL. The proposed method was applied to study of nateglinide in pure and pharmaceutical preparations.
dc.identifier.doi10.1134/S0030400X14010020
dc.identifier.endpage55
dc.identifier.issn0030-400X
dc.identifier.issn1562-6911
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84893791885
dc.identifier.scopusqualityQ4
dc.identifier.startpage52
dc.identifier.urihttps://doi.org/10.1134/S0030400X14010020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7177
dc.identifier.volume116
dc.identifier.wosWOS:000331085200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofOptics and Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPerformance Liquid-Chromatography
dc.subjectPrecolumn Derivatization
dc.subjectHuman Serum
dc.subjectHuman Plasma
dc.subjectHplc
dc.subject4-Chloro-7-Nitrobenzofurazan
dc.subjectAgent
dc.titleSpectrofluorimetric determination of nateglinide in pure and pharmaceutical preparations through derivatization with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
dc.typeArticle

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