Leptin Receptor Gene Polymorphisms in Some Turkish Donkey Populations

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dc.authorscopusid57200696504
dc.authorscopusid26028615800
dc.contributor.authorIşık, Raziye
dc.contributor.authorÖzdil, Fulya
dc.date.accessioned2022-05-11T14:07:12Z
dc.date.available2022-05-11T14:07:12Z
dc.date.issued2020
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.description.abstractLeptin receptor is a fundamental regulator in physiological functions of the regulation of food intake, energy homeostasis, immune function, and reproduction as well as on ovarian follicular cells on the placenta and lactating mammary glands. The aim of this study was to investigate the LEPR gene polymorphism in 60 donkeys reared in Thrace region of Turkey. A 585 bp long partial intron 6, exon 7, intron 7, and exon 8 regions of LEPR gene were amplified, and polymerase chain reaction products analyzed via DNA sequencing. A novel single-nucleotide polymorphism (SNP) was identified as g.713668A>G in the seventh exon region of LEPR gene. This novel SNP was first identified, and the partial DNA sequence of LEPR gene in donkeys was reported for the first time in this study, and these sequences were deposited to NCBI Genbank database with the accession number: MK807114-MK807115. The A>G transition revealed a silent mutation (CAA-CAG) in glutamine amino acid. This nucleotide mutation could cause the changes of secondary structure of protein and expression level of LEPR hormone. For this reason, additional studies are needed to reveal new SNPs and in the LEPR gene that may affect economic traits and structure of protein in donkey breeds. Copyright © 2019 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.jevs.2019.102823
dc.identifier.issn0737-0806
dc.identifier.pmid31864461
dc.identifier.scopus2-s2.0-85077152096
dc.identifier.scopusqualityQ2
dc.identifier.startpage102823
dc.identifier.urihttps://doi.org/10.1016/j.jevs.2019.102823
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5004
dc.identifier.volume84
dc.identifier.wosWOS:000504739100008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Raziye
dc.institutionauthorÖzdil, Fulya
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofJournal of equine veterinary science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA sequencing
dc.subjectDonkey
dc.subjectEquus asinus
dc.subjectLEPR gene
dc.subjectTurkey
dc.subjectleptin receptor
dc.subjectanimal
dc.subjectEquidae
dc.subjectfemale
dc.subjectgenetics
dc.subjectlactation
dc.subjectpregnancy
dc.subjectsingle nucleotide polymorphism
dc.subjectturkey (bird)
dc.subjectAnimals
dc.subjectEquidae
dc.subjectFemale
dc.subjectLactation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectPregnancy
dc.subjectReceptors, Leptin
dc.subjectTurkey
dc.titleLeptin Receptor Gene Polymorphisms in Some Turkish Donkey Populations
dc.typeArticle

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