Effect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0001-5590-0637
dc.authorid0000-0002-8084-7855
dc.authorscopusid56674583800
dc.authorscopusid23666416400
dc.authorscopusid35197435300
dc.authorscopusid7005912992
dc.authorscopusid56674439000
dc.authorscopusid56769801000
dc.authorscopusid57201362754
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidKARAARSLAN, Numan/I-6819-2019
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidOzbek, Hanefi/O-3472-2019
dc.contributor.authorKaraarslan, Numan
dc.contributor.authorBatmaz, Ahmet Güray
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÖzbek, Hanefi
dc.contributor.authorÇalışkan, Tezcan
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorAteş, Özkan
dc.date.accessioned2022-05-11T14:12:14Z
dc.date.available2022-05-11T14:12:14Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Beyin ve Sinir Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractNon-steroidal anti-inflammatory drugs (NSAIDs) that are applied through oral, injectable or topical routes have been widely used in painful and inflammatory musculoskeletal diseases. The current study aimed to determine whether naproxen, an aryl acetic acid derivative with analgesic and anti-inflammatory effects, has a toxic effect on human chondrocytes. Samples containing monolayer primary chondrocyte cultures were prepared following resection from osteochondral tissues obtained from patients with gonarthrosis. Cell viability, toxicity and proliferation and levels of stage-specific embryonic antigen-1, a precursor to human prechondrocytes, were evaluated spectrophotometrically. The results from the untreated control group were compared with those of the study groups, where naproxen was administered in varying doses (1-1,000 mu M). Surface morphologies of the cells were compared using inverted light and environmental scanning electron microscopy. Treatment groups were compared by analysis of variance with Tukey's honest difference post hoc test. P<0.01 was considered to indicate a statistically significant difference. The research revealed significant changes to proliferation and differentiation of chondrocytes in all treatment groups (P<0.01). Naproxen was demonstrated to suppress chondrocyte proliferation and differentiation, which may be an important factor to consider when prescribing this medication to patients.
dc.identifier.doi10.3892/etm.2018.6351
dc.identifier.endpage1654
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue3en_US
dc.identifier.pmid30186383
dc.identifier.scopus2-s2.0-85051114586
dc.identifier.scopusqualityN/A
dc.identifier.startpage1647
dc.identifier.urihttps://doi.org/10.3892/etm.2018.6351
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5459
dc.identifier.volume16
dc.identifier.wosWOS:000443738300011
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKaraarslan, Numan
dc.institutionauthorÇalışkan, Tezcan
dc.institutionauthorŞirin, Duygu Yaşar
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectaryl acetic acid
dc.subjectchondrotoxicity
dc.subjectproliferation
dc.subjectstage-specific embryonic antigen-1
dc.subjectMesenchymal Stem-Cells
dc.subjectBlood-Pressure
dc.subjectIn-Vitro
dc.subjectHuman Chondrocytes
dc.subjectSynovial-Fluid
dc.subjectNsaids
dc.subjectTransport
dc.subjectArthritis
dc.subjectIbuprofen
dc.subjectMembrane
dc.titleEffect of naproxen on proliferation and differentiation of primary cell cultures isolated from human cartilage tissue
dc.typeArticle

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