Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)

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dc.authorscopusid37002887000
dc.authorscopusid16203384500
dc.authorscopusid57867202100
dc.authorscopusid7005094713
dc.authorscopusid7003953248
dc.authorscopusid56348383300
dc.authorscopusid6603070081
dc.contributor.authorKayıkçı, Ömür
dc.contributor.authorMehtap, Ö.
dc.contributor.authorSarı, İ.
dc.contributor.authorDemirkan, F.
dc.contributor.authorBeyan, C.
dc.contributor.authorÇetin, G.
dc.contributor.authorTekgündüz, E.
dc.contributor.authorAkpınar, Seval
dc.date.accessioned2023-04-20T08:04:17Z
dc.date.available2023-04-20T08:04:17Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy. © 2022 by Turkish Society of Hematology Turkish Journal of Hematology, Published by Galenos Publishing House.
dc.identifier.doi10.4274/tjh.galenos.2022.2022.0052
dc.identifier.endpage177
dc.identifier.issn1300-7777
dc.identifier.issue3en_US
dc.identifier.pmid35678126
dc.identifier.scopus2-s2.0-85137000431
dc.identifier.scopusqualityQ3
dc.identifier.startpage170
dc.identifier.trdizinid1127363
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2022.2022.0052
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11069
dc.identifier.volume39
dc.identifier.wosWOS:000883473800003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.institutionauthorAkpınar, Seval
dc.language.isoen
dc.publisherTurkish Society of Hematology
dc.relation.ispartofTurkish Journal of Hematology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAutologous stem cell transplantation
dc.subjectLymphomas
dc.subjectNon-Hodgkin lymphoma
dc.subjectT-cell lymphomas
dc.subjectanaplastic lymphoma kinase
dc.subjectfluorodeoxyglucose f 18
dc.subjectantineoplastic agent
dc.subjectabdomen
dc.subjectadult
dc.subjectanaplastic large cell lymphoma
dc.subjectArticle
dc.subjectautologous hematopoietic stem cell transplantation
dc.subjectautologous stem cell transplantation
dc.subjectbiopsy
dc.subjectbone marrow biopsy
dc.subjectcancer patient
dc.subjectcancer prognosis
dc.subjectcancer survival
dc.subjectcomputer assisted tomography
dc.subjectfemale
dc.subjecthematopoietic cell
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectInternational Prognostic Index
dc.subjectliver function test
dc.subjectlymph node
dc.subjectmale
dc.subjectmulticenter study
dc.subjectneck
dc.subjectNon Cutaneous Peripheral T Cell Lymphoma
dc.subjectnonhodgkin lymphoma
dc.subjectoverall response rate
dc.subjectoverall survival
dc.subjectpelvis
dc.subjectperipheral T cell lymphoma
dc.subjectphysical examination
dc.subjectpositron emission tomography
dc.subjectprogression free survival
dc.subjectremission
dc.subjectretrospective study
dc.subjectrisk factor
dc.subjectsalvage therapy
dc.subjectthorax
dc.subjecttransplantation
dc.subjecttreatment outcome
dc.subjectautotransplantation
dc.subjectclinical trial
dc.subjecthematology
dc.subjecthematopoietic stem cell transplantation
dc.subjectpathology
dc.subjectperipheral T cell lymphoma
dc.subjectprocedures
dc.subjecttreatment outcome
dc.subjectAntineoplastic Combined Chemotherapy Protocols
dc.subjectHematology
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectHumans
dc.subjectLymphoma, T-Cell, Peripheral
dc.subjectRetrospective Studies
dc.subjectTransplantation, Autologous
dc.subjectTreatment Outcome
dc.titleReal-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)
dc.title.alternativeNon-kutanöz Periferik T-hücreli Lenfomalarda Klinik Özellikler ve Tedavi Sonuçlarına ilişkin Gerçek Yaşam Deneyimi:Türk Hematoloji Araştırma ve Eğitim Grubunun Çok Merkezli Çalışması
dc.typeArticle

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