Real-Life Experience Regarding Clinical Characteristics and Treatment Outcome in Non-Cutaneous Peripheral T-Cell Lymphomas: A Multicenter Study of the Turkish Hematology Research and Education Group (ThREG)
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Society of Hematology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Peripheral T-cell lymphomas (PTCLs) are an uncommon and quite heterogeneous group of disorders, representing only 10%-15% of all non-Hodgkin lymphomas. Although both molecular and clinical studies have increased in recent years, we still have little knowledge regarding real-life practice with PTCLs. In this study, we aimed to investigate the clinical characteristics and treatment outcomes of a large population-based cohort of patients presenting with systemic non-cutaneous PTCL. Materials and Methods: We conducted a multicenter retrospective analysis of 190 patients consecutively diagnosed and treated with non-cutaneous PTCLs between 2008 and 2016. Results: Considering all first-line treatment combinations, the overall response rate was 65.9% with 49.4% complete remission (n=81) and 16.5% partial response (n=27). The 5-year overall survival and event-free survival rates were significantly different between the transplant and non-transplant groups (p<0.01, and p=0.033, respectively). Conclusion: The retrospective analysis of a large volume of real-life data on the Turkish experience regarding non-cutaneous PTCL patients showed consistent results compared to other unselected PTCL cohorts with some minor differences in terms of survival and transplantation outcomes. The long-term outcome of patients who receive autologous hematopoietic cell transplantation as part of upfront consolidation or salvage therapy is favorable compared to patients who are unable to receive high-dose therapy. © 2022 by Turkish Society of Hematology Turkish Journal of Hematology, Published by Galenos Publishing House.
Açıklama
Anahtar Kelimeler
Autologous stem cell transplantation, Lymphomas, Non-Hodgkin lymphoma, T-cell lymphomas, anaplastic lymphoma kinase, fluorodeoxyglucose f 18, antineoplastic agent, abdomen, adult, anaplastic large cell lymphoma, Article, autologous hematopoietic stem cell transplantation, autologous stem cell transplantation, biopsy, bone marrow biopsy, cancer patient, cancer prognosis, cancer survival, computer assisted tomography, female, hematopoietic cell, human, human tissue, International Prognostic Index, liver function test, lymph node, male, multicenter study, neck, Non Cutaneous Peripheral T Cell Lymphoma, nonhodgkin lymphoma, overall response rate, overall survival, pelvis, peripheral T cell lymphoma, physical examination, positron emission tomography, progression free survival, remission, retrospective study, risk factor, salvage therapy, thorax, transplantation, treatment outcome, autotransplantation, clinical trial, hematology, hematopoietic stem cell transplantation, pathology, peripheral T cell lymphoma, procedures, treatment outcome, Antineoplastic Combined Chemotherapy Protocols, Hematology, Hematopoietic Stem Cell Transplantation, Humans, Lymphoma, T-Cell, Peripheral, Retrospective Studies, Transplantation, Autologous, Treatment Outcome
Kaynak
Turkish Journal of Hematology
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
39
Sayı
3
