Validated spectrofluorimetric method for the determination of tamsulosin in spiked human urine, pure and pharmaceutical preparations

Basit Öğe Kaydı
dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorscopusid34574169900
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.contributor.authorUlu, Sevgi Tatar
dc.date.accessioned2022-05-11T14:29:57Z
dc.date.available2022-05-11T14:29:57Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA novel, sensitive and selective spectrofluorimetric method was developed for the determination of tamsulosin in spiked human urine and pharmaceutical preparations. The proposed method is based on the reaction of tamsulosin with 1-dimethylaminonaphthalene-5-sulfonyl chloride in carbonate buffer pH10.5 to yield a highly fluorescent derivative. The described method was validated and the analytical parameters of linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, recovery and robustness were evaluated. The proposed method showed a linear dependence of the fluorescence intensity on drug concentration over the range 1.22 x 10(-7) to 7.35 x 10(-6)M. LOD and LOQ were calculated as 1.07 x 10(-7) and 3.23 x 10(-7)M, respectively. The proposed method was successfully applied for the determination of tamsulosin in pharmaceutical preparations and the obtained results were in good agreement with those obtained using the reference method. Copyright (c) 2013 John Wiley & Sons, Ltd.
dc.identifier.doi10.1002/bio.2534
dc.identifier.endpage242
dc.identifier.issn1522-7235
dc.identifier.issn1522-7243
dc.identifier.issue3en_US
dc.identifier.pmid23847119
dc.identifier.scopus2-s2.0-84898770865
dc.identifier.scopusqualityQ2
dc.identifier.startpage239
dc.identifier.urihttps://doi.org/10.1002/bio.2534
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7183
dc.identifier.volume29
dc.identifier.wosWOS:000334346000006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofLuminescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectderivatization
dc.subjecthuman urine
dc.subjectmethod validation
dc.subjectdansyl chloride
dc.subjectPerformance Liquid-Chromatography
dc.subjectHuman Plasma
dc.subjectMass-Spectrometry
dc.subjectSensitive Method
dc.subjectHydrochloride
dc.titleValidated spectrofluorimetric method for the determination of tamsulosin in spiked human urine, pure and pharmaceutical preparations
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
7183.pdf
Boyut:
256.17 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu