The preventive role of Spirulina platensis (Arthrospira platensis) in immune and oxidative insults in a stress-induced rat model

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dc.authorscopusid55921065100
dc.authorscopusid57226077600
dc.authorscopusid57226057097
dc.authorscopusid7005426982
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.authorKöşeli, Eda
dc.contributor.authorGurbanli, Rovshan
dc.contributor.authorAydın, Cenk
dc.date.accessioned2022-05-11T14:05:15Z
dc.date.available2022-05-11T14:05:15Z
dc.date.issued2021
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractIntroduction: There is a balance between oxidative stress, antioxidant capacity and immune response. Their roles in physiological and behavioural mechanisms are important for the maintenance of the organism's internal equilibrium. This study aimed to evaluate the antioxidant effects of the exogenous alga Spirulina platensis (Arthrospira platensis) in a stress-induced rat model, and to describe its possible mechanism of action. Material and Methods: Thirty-six adult male Sprague Dawley rats were separated into four groups: Control (C), stress (S), S. platensis (Sp), and S. platensis + stress (SpS). The rats in groups Sp and SpS were fed with 1,500 mg/kg b.w./day Spirulina platensis for 28 days. All rats were exposed to prolonged light phase conditions (18 h light : 6 h dark) for 14 days. The SpS and S groups were exposed to stress by being kept isolated and in a crowded environment. Blood samples were obtained by puncturing the heart on the 28th day. The effect of stress on serum corticosterone, oxidative stress markers (TOS, TAC, PON1, OSI) and immunological parameters (IL-2, IL-4, IFN-?) were tested. Also, the brain, heart, intestines (duodenum, ileum, and colon), kidney, liver, spleen, and stomach of the rats were weighed. Results: Serum corticosterone levels were higher in the S group than in the C group, and significantly lower in the SpS group than in the S group. Mean total antioxidant capacity were lower in the S group than in the C group, and Spirulina reversed this change. Although not significantly different, IL-2 was lower in the S group than in the C group. However, in the SpS group, IL-2 increased due to Spirulina platensis mitigating effects of stress. Conclusion: Male rats fed a diet with Spirulina platensis could experience significantly milder physiological changes during stress, although stress patterns may be different. Exogenous antioxidant supplements merit further investigation in animals and humans where the endogenous defence mechanism against stress may not be sufficient. © 2021 Sciendo. All rights reserved.
dc.identifier.doi10.2478/jvetres-2021-0033
dc.identifier.endpage200
dc.identifier.issn2450-7393
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85110295191
dc.identifier.scopusqualityQ2
dc.identifier.startpage193
dc.identifier.urihttps://doi.org/10.2478/jvetres-2021-0033
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4935
dc.identifier.volume65
dc.identifier.wosWOS:000663570700009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSeyidoğlu, Nilay
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofJournal of Veterinary Research (Poland)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorticosterone
dc.subjectImmune function
dc.subjectOxidant-antioxidant status
dc.subjectSpirulina (Arthrospira) platensis
dc.subjectStress
dc.subjectantioxidant
dc.subjectaryldialkylphosphatase
dc.subjectaryldialkylphosphatase 1
dc.subjectcatalase
dc.subjectcorticosterone
dc.subjectdianisidine
dc.subjectgamma interferon
dc.subjectglutathione peroxidase
dc.subjectinterleukin 2
dc.subjectinterleukin 4
dc.subjectinterleukin 6
dc.subjectmalonaldehyde
dc.subjectnitric oxide
dc.subjectoxidizing agent
dc.subjectsuperoxide dismutase
dc.subjecttestosterone
dc.subjectanimal cell
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectantioxidant assay
dc.subjectArthrospira platensis
dc.subjectArticle
dc.subjectblood vessel reactivity
dc.subjectbody weight
dc.subjectbrain
dc.subjectcolon
dc.subjectcolorimetry
dc.subjectcontrolled study
dc.subjectcorticosterone blood level
dc.subjectcost effectiveness analysis
dc.subjectdefense mechanism
dc.subjectdiet
dc.subjectdiet supplementation
dc.subjectduodenum
dc.subjectendoplasmic reticulum stress
dc.subjectenzyme linked immunosorbent assay
dc.subjectheart
dc.subjectileum
dc.subjectimmunization
dc.subjectkidney
dc.subjectliver
dc.subjectmale
dc.subjectmicroalga
dc.subjectnonhuman
dc.subjectorgan weight
dc.subjectoxidation
dc.subjectoxidative stress
dc.subjectphysiological stress
dc.subjectrat
dc.subjectspectrophotometry
dc.subjectspleen
dc.subjectstomach
dc.subjecttestis tissue
dc.titleThe preventive role of Spirulina platensis (Arthrospira platensis) in immune and oxidative insults in a stress-induced rat model
dc.typeArticle

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