The preventive role of Spirulina platensis (Arthrospira platensis) in immune and oxidative insults in a stress-induced rat model
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Dosyalar
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sciendo
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: There is a balance between oxidative stress, antioxidant capacity and immune response. Their roles in physiological and behavioural mechanisms are important for the maintenance of the organism's internal equilibrium. This study aimed to evaluate the antioxidant effects of the exogenous alga Spirulina platensis (Arthrospira platensis) in a stress-induced rat model, and to describe its possible mechanism of action. Material and Methods: Thirty-six adult male Sprague Dawley rats were separated into four groups: Control (C), stress (S), S. platensis (Sp), and S. platensis + stress (SpS). The rats in groups Sp and SpS were fed with 1,500 mg/kg b.w./day Spirulina platensis for 28 days. All rats were exposed to prolonged light phase conditions (18 h light : 6 h dark) for 14 days. The SpS and S groups were exposed to stress by being kept isolated and in a crowded environment. Blood samples were obtained by puncturing the heart on the 28th day. The effect of stress on serum corticosterone, oxidative stress markers (TOS, TAC, PON1, OSI) and immunological parameters (IL-2, IL-4, IFN-?) were tested. Also, the brain, heart, intestines (duodenum, ileum, and colon), kidney, liver, spleen, and stomach of the rats were weighed. Results: Serum corticosterone levels were higher in the S group than in the C group, and significantly lower in the SpS group than in the S group. Mean total antioxidant capacity were lower in the S group than in the C group, and Spirulina reversed this change. Although not significantly different, IL-2 was lower in the S group than in the C group. However, in the SpS group, IL-2 increased due to Spirulina platensis mitigating effects of stress. Conclusion: Male rats fed a diet with Spirulina platensis could experience significantly milder physiological changes during stress, although stress patterns may be different. Exogenous antioxidant supplements merit further investigation in animals and humans where the endogenous defence mechanism against stress may not be sufficient. © 2021 Sciendo. All rights reserved.
Açıklama
Anahtar Kelimeler
Corticosterone, Immune function, Oxidant-antioxidant status, Spirulina (Arthrospira) platensis, Stress, antioxidant, aryldialkylphosphatase, aryldialkylphosphatase 1, catalase, corticosterone, dianisidine, gamma interferon, glutathione peroxidase, interleukin 2, interleukin 4, interleukin 6, malonaldehyde, nitric oxide, oxidizing agent, superoxide dismutase, testosterone, animal cell, animal experiment, animal model, animal tissue, antioxidant activity, antioxidant assay, Arthrospira platensis, Article, blood vessel reactivity, body weight, brain, colon, colorimetry, controlled study, corticosterone blood level, cost effectiveness analysis, defense mechanism, diet, diet supplementation, duodenum, endoplasmic reticulum stress, enzyme linked immunosorbent assay, heart, ileum, immunization, kidney, liver, male, microalga, nonhuman, organ weight, oxidation, oxidative stress, physiological stress, rat, spectrophotometry, spleen, stomach, testis tissue
Kaynak
Journal of Veterinary Research (Poland)
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
65
Sayı
2
