Ultrasensitive electrochemical detection of cancer associated biomarker HER3 based on anti-HER3 biosensor

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dc.authorscopusid55988499900
dc.authorscopusid6506764918
dc.authorwosidSezgintürk, Mustafa Kemal/AAY-1439-2021
dc.contributor.authorSonuç Karaboğa, Münteha Nur
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.date.accessioned2022-05-11T14:15:41Z
dc.date.available2022-05-11T14:15:41Z
dc.date.issued2014
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.departmentYüksekokullar, Sağlık Yüksekokulu, Beslenme ve Diyetetik Bölümü
dc.description.abstractThe development of a new impedimetric biosensor for the detection of HER3, based on self-assembled monolayers (SAMs) of 4-aminothiophenol on gold electrodes, is reported. Anti-HER3 was used as a biorecognition element for the first time in an impedimetric biosensor. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) techniques were applied to characterize the immobilization process and to detect HER3. To provide the best biosensor response all experimental parameters were optimized. In addition, Kramers-Kronigs transform was also performed on the immobilization and measurement processes successfully. The biosensor had a linear detection range of 0.4-2.4 pg/mL. The chrono-impedance technique to real time monitor the interaction between HER3 and anti-HER3 is also implemented. The biosensor has exhibited good repeatability and reproducibility. To demonstrate the feasibility of the biosensor in practical analysis, the artificial serum samples were experienced. (C) 2013 Elsevier B.V. All rights reserved.
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [109 T 172]
dc.description.sponsorshipSupport from TUBITAK (The Scientific and Technological Research Council of Turkey, Project number: 109 T 172) is greatly acknowledged.
dc.identifier.doi10.1016/j.talanta.2013.11.090
dc.identifier.endpage361
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.pmid24468382
dc.identifier.scopus2-s2.0-84891686219
dc.identifier.scopusqualityQ1
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2013.11.090
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6027
dc.identifier.volume120
dc.identifier.wosWOS:000331917700049
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorSonuç Karaboğa, Münteha Nur
dc.institutionauthorSezgintürk, Mustafa Kemal
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofTalanta
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHER3
dc.subjectAnti-HER3
dc.subjectBiosensor
dc.subjectElectrochemical impedance spectroscopy
dc.subjectCancer biomarker
dc.subjectC-Erbb-3 Protein Expression
dc.subjectGrowth-Factor Receptors
dc.subjectErbb3
dc.subjectDispersion
dc.subjectCarcinoma
dc.subjectAntibody
dc.titleUltrasensitive electrochemical detection of cancer associated biomarker HER3 based on anti-HER3 biosensor
dc.typeArticle

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