Effects of alpha lipoic acid and vitamin C supplementation on transforming growth factor alpha (TGF alpha) and transforming growth factor beta 2 (TGF beta 2) secretion in testicular tissue of diabetic rats

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dc.authorscopusid34971025700
dc.authorscopusid37121662100
dc.authorscopusid56480260200
dc.authorscopusid27667663200
dc.authorscopusid25637811600
dc.authorwosidbakır, buket/ABA-8248-2020
dc.contributor.authorEliş Yıldız, Sevda
dc.contributor.authorBakır, Buket
dc.contributor.authorUslu, Hamit
dc.contributor.authorKaradağ Sarı, Ebru
dc.contributor.authorKaraman, Musa
dc.date.accessioned2022-05-11T14:42:27Z
dc.date.available2022-05-11T14:42:27Z
dc.date.issued2015
dc.departmentFakülteler, Veteriner Fakültesi, Temel Bilimler Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe effects of alpha lipoic acid and vitamin C supplementation on TGF alpha and TGF beta 2 secretion in the testicular tissue of streptozotocin-induced diabetic rats were examined by immunohistochemical methods. Rats were divided into 5 groups; group 1 (control), 2 (diabetic control), 3 (diabetes + alpha lipoic acid), 4 (diabetes + vitamin C), and 5 (diabetes + alpha lipoic acid + vitamin C). Hematoxylin and eosin staining was performed in order to examine testicular tissue histopathologically. The streptavidin-biotin-peroxidase complex method was used for histological examination and determination of TGF alpha and TGF beta 2 localization in the testicular tissue. Regarding fasting blood glucose levels, the lowest blood glucose level was detected in group 3. Fewer pathological histopathological findings were observed in groups treated with alpha lipoic acid, vitamin C, and alpha lipoic acid + vitamin C compared to the diabetes group. TGF alpha and TGF beta 2 secretions increased in groups 3, 4, and 5 compared to group 2. In conclusion, exogenous administration of alpha lipoic acid, vitamin C, and alpha lipoic acid + vitamin C increased TGF alpha and TGF beta 2 secretion in streptozotocin-induced diabetic rats.
dc.identifier.doi10.3906/vet-1407-32
dc.identifier.endpage56
dc.identifier.issn1300-0128
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84920901599
dc.identifier.scopusqualityQ3
dc.identifier.startpage50
dc.identifier.urihttps://doi.org/10.3906/vet-1407-32
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9378
dc.identifier.volume39
dc.identifier.wosWOS:000347678600008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorBakır, Buket
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAlpha lipoic acid
dc.subjectdiabetes
dc.subjectvitamin C
dc.subjectTGF alpha
dc.subjectTGF beta 2
dc.subjectOxidative Stress
dc.subjectAntioxidant
dc.subjectEgf
dc.subjectPrevention
dc.subjectExpression
dc.subjectMellitus
dc.subjectReceptor
dc.titleEffects of alpha lipoic acid and vitamin C supplementation on transforming growth factor alpha (TGF alpha) and transforming growth factor beta 2 (TGF beta 2) secretion in testicular tissue of diabetic rats
dc.typeArticle

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