Electroanalytical Characterization of Montelukast Sodium and Its Voltammetric Determination in Pharmaceutical Dosage Form and Biological Fluids

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dc.authorid0000-0001-5153-8319
dc.authorscopusid57189076493
dc.authorscopusid25422504200
dc.authorscopusid12784153100
dc.authorwosidOzturk, funda/G-9435-2014
dc.contributor.authorÇölkesen, Bernu
dc.contributor.authorÖztürk, Funda
dc.contributor.authorErden, Pınar Esra
dc.date.accessioned2022-05-11T14:30:54Z
dc.date.available2022-05-11T14:30:54Z
dc.date.issued2016
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe electrochemical properties of montelukast sodium (MKST) at zinc oxide nanoparticles modified carbon paste electrode were investigated by cyclic voltammetry and square wave voltammetry. All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of montelukast sodium at about -0.7 vs. Ag/AgCl at pH 2.3 in methanol-Britton-Robinson buffer mixture. This adsorptive character of the molecule was used to develop a novel, validated, rapid, selective and simple square wave cathodic adsorptive stripping voltammeric method for the direct determination of montelukast sodium in pharmaceutical and biological fluids without time-consuming steps prior to drug assay. Peak current of electrochemical reduction of montelukast sodium was found to vary linearly with the concentration in the range from 1.0 x 10(-8) to 1.28 x 10(-6) mol L-1. In this method, limit of detection was found to be 7.7 x 10(-9) mol L-1. The method was applied to determine the content of MKST tablet and spiked human serum.
dc.description.sponsorshipNamik Kemal UniversityNamik Kemal University [NKU BAP.00.10.YL.14.03]
dc.description.sponsorshipThis work was supported by the Research Fund of the Namik Kemal University. Project No. NKU BAP.00.10.YL.14.03. The authors would like to thank to Prof Esma Kilic for her valuable comments and suggestions on the manuscript.
dc.identifier.doi10.5935/0103-5053.20150337
dc.identifier.endpage856
dc.identifier.issn0103-5053
dc.identifier.issn1678-4790
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84965056662
dc.identifier.scopusqualityQ3
dc.identifier.startpage849
dc.identifier.urihttps://doi.org/10.5935/0103-5053.20150337
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7223
dc.identifier.volume27
dc.identifier.wosWOS:000376510300006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÇölkesen, Bernu
dc.institutionauthorÖztürk, Funda
dc.language.isoen
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectzinc oxide nanoparticle
dc.subjectsquare wave cathodic adsorptive stripping voltammetry
dc.subjectmontelukast sodium
dc.subjectpharmaceutical preparation
dc.subjecthuman serum
dc.subjectZno Nanoparticles
dc.subjectCarbon
dc.subjectElectrodes
dc.titleElectroanalytical Characterization of Montelukast Sodium and Its Voltammetric Determination in Pharmaceutical Dosage Form and Biological Fluids
dc.typeArticle

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