Electroanalytical Characterization of Montelukast Sodium and Its Voltammetric Determination in Pharmaceutical Dosage Form and Biological Fluids
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Brasileira Quimica
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The electrochemical properties of montelukast sodium (MKST) at zinc oxide nanoparticles modified carbon paste electrode were investigated by cyclic voltammetry and square wave voltammetry. All studies were based on the irreversible and adsorption-controlled electrochemical reduction signal of montelukast sodium at about -0.7 vs. Ag/AgCl at pH 2.3 in methanol-Britton-Robinson buffer mixture. This adsorptive character of the molecule was used to develop a novel, validated, rapid, selective and simple square wave cathodic adsorptive stripping voltammeric method for the direct determination of montelukast sodium in pharmaceutical and biological fluids without time-consuming steps prior to drug assay. Peak current of electrochemical reduction of montelukast sodium was found to vary linearly with the concentration in the range from 1.0 x 10(-8) to 1.28 x 10(-6) mol L-1. In this method, limit of detection was found to be 7.7 x 10(-9) mol L-1. The method was applied to determine the content of MKST tablet and spiked human serum.
Açıklama
Anahtar Kelimeler
zinc oxide nanoparticle, square wave cathodic adsorptive stripping voltammetry, montelukast sodium, pharmaceutical preparation, human serum, Zno Nanoparticles, Carbon, Electrodes
Kaynak
Journal of the Brazilian Chemical Society
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
27
Sayı
5
