Carbazole substituted BODIPY dyes: Synthesis, photophysical properties and antitumor activity

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dc.authorid0000-0001-6530-0205
dc.authorid0000-0002-7347-2223
dc.authorid0000-0001-9386-4892
dc.authorid0000-0003-3316-7002
dc.authorscopusid55308985300
dc.authorscopusid26666236900
dc.authorscopusid55326408200
dc.authorscopusid54998317700
dc.authorscopusid15135182300
dc.authorwosidÇOŞUT, Bünyemin/X-7554-2019
dc.authorwosidk, h/ABA-1339-2020
dc.authorwosidSengul, Ibrahim Fazil/AAG-4368-2019
dc.contributor.authorŞengül, İbrahim Fazıl
dc.contributor.authorOkutan, Elif
dc.contributor.authorKandemir, Hakan
dc.contributor.authorAstarcı, Erhan
dc.contributor.authorÇoşut, Bünyemin
dc.date.accessioned2022-05-11T14:29:59Z
dc.date.available2022-05-11T14:29:59Z
dc.date.issued2015
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractIn this study, two different BODIPYs containing carbazole groups at the mesa position were designed and synthesized. All compounds were fully characterized by elemental analysis, FT-IR, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMR spectroscopy. The photophysical properties of the new compounds were investigated by means of absorption and fluorescence spectroscopies in dilute dichloromethane solutions. We were also interested in the biological activity of these two novel carbazole-linked BODIPYs, particularly concerning their ability to inhibit human colon cancer HT29 cell lines. The photophysical studies revealed strong donor acceptor interaction between carbazole and BODIPY and follow the order compound 5 > compound 4. Also, preliminary assay showed that compound 5 possessed higher cytotoxic activity than compound 4, with IC50 values of 8.3 ng/mL and 21.7 ng/mL respectively. (C) 2015 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z159]
dc.description.sponsorshipWe wish to thank TUBITAK (project number -113Z159) for financial support.
dc.identifier.doi10.1016/j.dyepig.2015.07.025
dc.identifier.endpage38
dc.identifier.issn0143-7208
dc.identifier.issn1873-3743
dc.identifier.scopus2-s2.0-84938542442
dc.identifier.scopusqualityQ1
dc.identifier.startpage32
dc.identifier.urihttps://doi.org/10.1016/j.dyepig.2015.07.025
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7190
dc.identifier.volume123
dc.identifier.wosWOS:000367768300005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Hakan
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofDyes and Pigments
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCarbazole
dc.subjectEnergy transfer
dc.subjectFluorescence
dc.subjectBiological activity
dc.subjectBorondipyrromethenes
dc.subjectLifetime
dc.subjectEnergy-Transfer
dc.subjectLong-Wavelength
dc.subjectSolar-Cells
dc.subjectFluorescence
dc.subjectDerivatives
dc.subjectAbsorption
dc.subjectProtein
dc.subjectRed
dc.titleCarbazole substituted BODIPY dyes: Synthesis, photophysical properties and antitumor activity
dc.typeArticle

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