Carbazole substituted BODIPY dyes: Synthesis, photophysical properties and antitumor activity
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Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier Sci Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
In this study, two different BODIPYs containing carbazole groups at the mesa position were designed and synthesized. All compounds were fully characterized by elemental analysis, FT-IR, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, H-1 and C-13 NMR spectroscopy. The photophysical properties of the new compounds were investigated by means of absorption and fluorescence spectroscopies in dilute dichloromethane solutions. We were also interested in the biological activity of these two novel carbazole-linked BODIPYs, particularly concerning their ability to inhibit human colon cancer HT29 cell lines. The photophysical studies revealed strong donor acceptor interaction between carbazole and BODIPY and follow the order compound 5 > compound 4. Also, preliminary assay showed that compound 5 possessed higher cytotoxic activity than compound 4, with IC50 values of 8.3 ng/mL and 21.7 ng/mL respectively. (C) 2015 Elsevier Ltd. All rights reserved.
Description
Keywords
Carbazole, Energy transfer, Fluorescence, Biological activity, Borondipyrromethenes, Lifetime, Energy-Transfer, Long-Wavelength, Solar-Cells, Fluorescence, Derivatives, Absorption, Protein, Red
Journal or Series
Dyes and Pigments
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
123
