The Association of ERG and c-erbB2 Expressions With Gleason Scoring in Adenocarcinomas of the Prostate

Basit Öğe Kaydı
dc.authoridkarabag, sevil/0000-0002-8855-3798
dc.contributor.authorDag, Kenan
dc.contributor.authorKarabağ, Sevil
dc.date.accessioned2023-05-06T17:19:33Z
dc.date.available2023-05-06T17:19:33Z
dc.date.issued2022
dc.departmentEnstitüler, Sağlık Bilimleri Enstitüsü, Tümör Biyolojisi ve İmmünolojisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.description.abstractBACKGROUND/AIM: We aimed to determine erythroblast transformation-specific-related gene (ERG) and c-erbB2 expression in patients with adenocarcinoma of the prostate and to investigate the association of these proteins with tumor growth and/or Gleason score, which is the main prognostic marker in these patients. MATERIALS AND METHODS: Radical prostatectomy materials of 59 patients with acinar adenocarcinoma were included in this study. Immunohistochemical analysis for ERG and c-erbB2 was performed. The association of ERG and c-erbB2 expressions with International Society of Urologic Pathologists (ISUP) grade, tumor volume and patient age was investigated. RESULTS: ISUP grade was 1 (equivalent to a Gleason score of 6) in 23 tumors while the rest of the cases were Gleason score >6 tumors. ERG expression was detected in 37.5% of the cases. None of the cases had c-erbB2 expression. There was no significant difference in ERG staining between the low-risk (ISUP 1) and high-risk (ISUP >1) groups (p=0.602). Evaluation of all ISUP groups with the Kruskal-Wallis test showed no significant difference across the groups in terms of ERG expression (p=0.374). CONCLUSION: The present study reflects the ERG expression rate (37.5%) in patients with carcinoma of the prostate in Turkey. Our findings support that ERG overexpression is involved in the pathogenesis but has no association with histological grade in prostate carcinoma.
dc.identifier.doi10.4274/cjms.2021.2021-117
dc.identifier.endpage200
dc.identifier.issn2149-7893
dc.identifier.issn2536-507X
dc.identifier.issue2en_US
dc.identifier.startpage196
dc.identifier.trdizinid1121866
dc.identifier.urihttps://doi.org/10.4274/cjms.2021.2021-117
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11849
dc.identifier.volume7
dc.identifier.wosWOS:000886750700008
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorDag, Kenan
dc.institutionauthorKarabağ, Sevil
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofCyprus Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectProstate carcinoma
dc.subjectGleason score
dc.subjectERG
dc.subjectc-erbB2
dc.subjectGene Amplification
dc.subjectTranscription Factor
dc.subjectProtein Expression
dc.subjectCancer
dc.subjectHer-2/Neu
dc.subjectFusion
dc.subjectOverexpression
dc.subjectOncoprotein
dc.subjectSociety
dc.titleThe Association of ERG and c-erbB2 Expressions With Gleason Scoring in Adenocarcinomas of the Prostate
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
11849.pdf
Boyut:
1.33 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Sağlık Bilimleri Enstitüsü Diğer Koleksiyonu
Tıp Fakültesi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu