The Association of ERG and c-erbB2 Expressions With Gleason Scoring in Adenocarcinomas of the Prostate
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Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Publ House
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
BACKGROUND/AIM: We aimed to determine erythroblast transformation-specific-related gene (ERG) and c-erbB2 expression in patients with adenocarcinoma of the prostate and to investigate the association of these proteins with tumor growth and/or Gleason score, which is the main prognostic marker in these patients. MATERIALS AND METHODS: Radical prostatectomy materials of 59 patients with acinar adenocarcinoma were included in this study. Immunohistochemical analysis for ERG and c-erbB2 was performed. The association of ERG and c-erbB2 expressions with International Society of Urologic Pathologists (ISUP) grade, tumor volume and patient age was investigated. RESULTS: ISUP grade was 1 (equivalent to a Gleason score of 6) in 23 tumors while the rest of the cases were Gleason score >6 tumors. ERG expression was detected in 37.5% of the cases. None of the cases had c-erbB2 expression. There was no significant difference in ERG staining between the low-risk (ISUP 1) and high-risk (ISUP >1) groups (p=0.602). Evaluation of all ISUP groups with the Kruskal-Wallis test showed no significant difference across the groups in terms of ERG expression (p=0.374). CONCLUSION: The present study reflects the ERG expression rate (37.5%) in patients with carcinoma of the prostate in Turkey. Our findings support that ERG overexpression is involved in the pathogenesis but has no association with histological grade in prostate carcinoma.
Açıklama
Anahtar Kelimeler
Prostate carcinoma, Gleason score, ERG, c-erbB2, Gene Amplification, Transcription Factor, Protein Expression, Cancer, Her-2/Neu, Fusion, Overexpression, Oncoprotein, Society
Kaynak
Cyprus Journal Of Medical Sciences
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
7
Sayı
2
