Residue packing in globular and intrinsically disordered proteins

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dc.authorscopusid57200421461
dc.authorscopusid8754351000
dc.contributor.authorAydinkal, R.M.
dc.contributor.authorBağcı, Elife Zerrin
dc.date.accessioned2022-05-11T14:03:11Z
dc.date.available2022-05-11T14:03:11Z
dc.date.issued2018
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description.abstractIntrinsically disordered proteins (IDPs)/regions do not have well-defined secondary and tertiary structures, however, they are functional and it is critical to gain a deep understanding of their residue packing. The shape distributions methodology, which is usually utilized in pattern recognition, clustering, and classification studies in computer science, may be adopted to study the residue packing of the proteins. In this study, shape distributions of the globular proteins and IDPs were obtained to shed light on the residue packing of their structures. The shape feature that was used is the sphericity of tetrahedra obtained by Delaunay Tessellation of points of C? coordinates. Then the sphericity probability distributions were compared by using Principal Component Analysis. This computational structural study shows that the set of IDPs constitute a more diverse set than the set of globular proteins in terms of the geometrical properties of their network structures. © 2018 Wiley Periodicals, Inc.
dc.description.sponsorshipAuthors appreciate the kind support and suggestions from Turkan Haliloglu.
dc.identifier.doi10.1002/prot.25459
dc.identifier.endpage438
dc.identifier.issn0887-3585
dc.identifier.issue4en_US
dc.identifier.pmid29341251
dc.identifier.scopus2-s2.0-85041189995
dc.identifier.scopusqualityQ1
dc.identifier.startpage434
dc.identifier.urihttps://doi.org/10.1002/prot.25459
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4634
dc.identifier.volume86
dc.identifier.wosWOS:000426597100006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBağcı, Elife Zerrin
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofProteins: Structure, Function and Bioinformatics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDelaunay Tessellation
dc.subjectintrinsically disordered proteins
dc.subjectPrincipal Component Analysis
dc.subjectresidue packing
dc.subjectshape distributions
dc.subjectsphericity of tetrahedra
dc.subjectglobular protein
dc.subjectintrinsically disordered protein
dc.subjectintrinsically disordered protein
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectphysical parameters
dc.subjectprincipal component analysis
dc.subjectpriority journal
dc.subjectprotein function
dc.subjectprotein structure
dc.subjectresidue packing
dc.subjectsphericity
dc.subjectanimal
dc.subjectchemistry
dc.subjecthuman
dc.subjectmolecular model
dc.subjectprobability
dc.subjectprotein database
dc.subjectprotein secondary structure
dc.subjectAnimals
dc.subjectDatabases, Protein
dc.subjectHumans
dc.subjectIntrinsically Disordered Proteins
dc.subjectModels, Molecular
dc.subjectPrincipal Component Analysis
dc.subjectProbability
dc.subjectProtein Structure, Secondary
dc.titleResidue packing in globular and intrinsically disordered proteins
dc.typeArticle

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