Residue packing in globular and intrinsically disordered proteins
Yükleniyor...
Dosyalar
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley and Sons Inc.
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Intrinsically disordered proteins (IDPs)/regions do not have well-defined secondary and tertiary structures, however, they are functional and it is critical to gain a deep understanding of their residue packing. The shape distributions methodology, which is usually utilized in pattern recognition, clustering, and classification studies in computer science, may be adopted to study the residue packing of the proteins. In this study, shape distributions of the globular proteins and IDPs were obtained to shed light on the residue packing of their structures. The shape feature that was used is the sphericity of tetrahedra obtained by Delaunay Tessellation of points of C? coordinates. Then the sphericity probability distributions were compared by using Principal Component Analysis. This computational structural study shows that the set of IDPs constitute a more diverse set than the set of globular proteins in terms of the geometrical properties of their network structures. © 2018 Wiley Periodicals, Inc.
Açıklama
Anahtar Kelimeler
Delaunay Tessellation, intrinsically disordered proteins, Principal Component Analysis, residue packing, shape distributions, sphericity of tetrahedra, globular protein, intrinsically disordered protein, intrinsically disordered protein, Article, controlled study, physical parameters, principal component analysis, priority journal, protein function, protein structure, residue packing, sphericity, animal, chemistry, human, molecular model, probability, protein database, protein secondary structure, Animals, Databases, Protein, Humans, Intrinsically Disordered Proteins, Models, Molecular, Principal Component Analysis, Probability, Protein Structure, Secondary
Kaynak
Proteins: Structure, Function and Bioinformatics
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
86
Sayı
4
