Limitations of Using Mass Action Kinetics Method in Modeling Biochemical Systems: Illustration for a Second Order Reaction

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dc.authorid0000-0001-5920-0400
dc.authorscopusid44861780000
dc.authorscopusid8754351000
dc.authorwosidBağcı, Elife Zerrin/A-9660-2016
dc.contributor.authorSayıklı, Çiğdem
dc.contributor.authorBağcı, Elife Zerrin
dc.date.accessioned2022-05-11T14:28:27Z
dc.date.available2022-05-11T14:28:27Z
dc.date.issued2011
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.description11th International Conference on Computational Science and Its Applications (ICCSA) -- JUN 20-23, 2011 -- Univ Cantabria, Santander, SPAIN
dc.description.abstractMathematical models for solving the nonlinear interactions in biological systems are a major component of computational systems biology. Deterministic method that is generally employed in these models assumes that the number of molecules in the well mixed reaction medium is large. When these assumptions are not valid, the system is stochastic. In deterministic methods, mass action kinetics terms are usually included. Herein, we illustrate that the results of deterministic mass action kinetics methods do not necessarily represent the average behavior of stochastic systems with a simple example of second order reaction.
dc.description.sponsorshipKyushu Sangyo Univ, Univ Perugia, Monash Univ, Univ Basilicata, Univ Cantabria, Dept Appl Math & Computat Sci, Univ Cantabria, Dept Math, Stat & Computat, Univ Cantabria, Fac Sci, Univ Cantabria, Vicerrector Res & Knowledge Transfer, Cantabria Campus Int, Municipal Santander, Reg Govt Cantabria, Spanish Minist Sci & Innovat, GeoConnex, Vector1 Media
dc.identifier.endpage526
dc.identifier.isbn978-3-642-21933-7
dc.identifier.issn0302-9743
dc.identifier.scopus2-s2.0-79960288738
dc.identifier.scopusqualityQ3
dc.identifier.startpage521
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6833
dc.identifier.volume6786
dc.identifier.wosWOS:000305831700042
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSayıklı, Çiğdem
dc.institutionauthorBağcı, Elife Zerrin
dc.language.isoen
dc.publisherSpringer-Verlag Berlin
dc.relation.ispartofComputational Science and Its Applications - Iccsa 2011, Pt V
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcomputational systems biology
dc.subjectmass action kinetics
dc.subjectdeterministic methods
dc.subjectillustration of stochasticity concept
dc.subjectstochasticity in biochemical systems
dc.subjectNetworks
dc.titleLimitations of Using Mass Action Kinetics Method in Modeling Biochemical Systems: Illustration for a Second Order Reaction
dc.typeConference Object

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