Limitations of Using Mass Action Kinetics Method in Modeling Biochemical Systems: Illustration for a Second Order Reaction
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Dosyalar
Tarih
2011
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer-Verlag Berlin
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Mathematical models for solving the nonlinear interactions in biological systems are a major component of computational systems biology. Deterministic method that is generally employed in these models assumes that the number of molecules in the well mixed reaction medium is large. When these assumptions are not valid, the system is stochastic. In deterministic methods, mass action kinetics terms are usually included. Herein, we illustrate that the results of deterministic mass action kinetics methods do not necessarily represent the average behavior of stochastic systems with a simple example of second order reaction.
Açıklama
11th International Conference on Computational Science and Its Applications (ICCSA) -- JUN 20-23, 2011 -- Univ Cantabria, Santander, SPAIN
Anahtar Kelimeler
computational systems biology, mass action kinetics, deterministic methods, illustration of stochasticity concept, stochasticity in biochemical systems, Networks
Kaynak
Computational Science and Its Applications - Iccsa 2011, Pt V
WoS Q Değeri
N/A
Scopus Q Değeri
Q3
Cilt
6786
