Synthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities

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dc.contributor.authorTürkyılmaz, Murat
dc.contributor.authorDönmez, Murat
dc.contributor.authorAteş, Murat
dc.date.accessioned2023-04-20T08:08:34Z
dc.date.available2023-04-20T08:08:34Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Coğrafya Bölümü
dc.description.abstractIn this study, theophylline (1) compounds were synthesized with addition of 2-bromoetha-nol, 2-bromoacetamide and methyl-2-bromoacetate to attain symmetric connections to NHCs (2a–c). New complexes containing the symmetric N-heterocyclic carbene (NHC) ligands were synthesized using azolium salts in dimethyl formamide (DMF). After the NHC predecessor compounds reacted with Ag2O, Ag(I)-NHC complexes were synthesized in the following: 7,9-di-(2-hydroxyethyl)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-dionedium silver(I)bromide (3a), 7,9-di(acetamide)-8,9-dihydro-1,3-dimethyl-1H-purine-2,6(3H,7H)-di-ondium silver(I)bromide (3b) and 7,9-di(methylacetate)-8,9-dihydro-1,3-dimethyl-1H-pu-rine-2,6(3H,7H)-diondiumsilver(I)bromide (3c). Both synthesized NHC predecessors (2a-c) and Ag(I)-NHC complexes (3a-c) were described by FTIR, 1H-NMR, 13C-NMR, liquid and solid-state conductivity values, TGA analysis, melting point analysis and XRD spectroscopy. In-vitro antibacterial activities of NHC-predecessors and Ag(I)-NHC complexes were tested against gram-positive bacteria (Staphylococcus Aureus and Bacillus Cereus), gram-negative bacteria (Escherichia Coli and Listeria Monocytogenes), and fungus (Candida Albicans) in Tryptic Soy Broth method. Ag(I)-NHC complexes showed higher antibacterial activity than pure NHC predecessors. The lowest microbial inhibition concentration (MIC) value of compound 3a was obtained as 11.56 ?g/ml for Escherichia Coli and 11.52 ?g/ml for Staphylococcus Aureus. All tested complexes displayed antimicrobial activity with different results.
dc.identifier.doi10.47481/jscmt.1117139
dc.identifier.endpage61
dc.identifier.issn2458-973X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85138697454
dc.identifier.scopusqualityN/A
dc.identifier.startpage53
dc.identifier.urihttps://doi.org/10.47481/jscmt.1117139
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/533168
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11350
dc.identifier.volume7
dc.indekslendigikaynakScopus
dc.institutionauthorTürkyılmaz, Murat
dc.institutionauthorDönmez, Murat
dc.institutionauthorAteş, Murat
dc.language.isoen
dc.relation.ispartofJournal of sustainable construction materials and technologies (Online)
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSEM analysis.
dc.subjectCandida Albicans
dc.subjecttheophylline
dc.subjectAntimicrobial activity
dc.titleSynthesis of Pincer type carbene andtheir Ag(I)-NHC complexes, and their Antimicrobial activities
dc.typeArticle

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