Synthesis, structural characterization and cytotoxicity of the antimony(III) chloride complex with N,N-dicyclohexyldithiooxamide

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dc.authorid0000-0003-3164-0038
dc.authorid0000-0003-3264-2406
dc.authorid0000-0003-0377-2260
dc.authorid0000-0001-9556-6266
dc.authorid0000-0001-6727-2711
dc.authorid0000-0003-1188-6233
dc.authorid0000-0001-7202-9169
dc.authorscopusid36785856200
dc.authorscopusid55227384500
dc.authorscopusid46860923200
dc.authorscopusid6507202525
dc.authorscopusid57209326301
dc.authorscopusid7005646655
dc.authorscopusid7004310002
dc.authorwosidürgüt, ozan suleyman/ABA-5795-2020
dc.authorwosidOzturk, Ibrahim Ismet/K-1352-2013
dc.authorwosidGrze?kiewicz, Anita/E-1315-2018
dc.authorwosidKourkoumelis, Nikolaos/B-8555-2009
dc.authorwosidHadjikakou, Sotiris K./I-2909-2019
dc.contributor.authorÖztürk, İbrahim İsmet
dc.contributor.authorÜrgüt, Ozan
dc.contributor.authorBanti, Christina N.
dc.contributor.authorKourkoumelis, Nikolaos
dc.contributor.authorOwczarzak, A. M.
dc.contributor.authorKubicki, M.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2022-05-11T14:29:52Z
dc.date.available2022-05-11T14:29:52Z
dc.date.issued2013
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThe reaction of antimony(III) chloride with the bidentate substituted dithiooxamide ligand, N,N-dicyclohexyldithiooxamide (HDTOA), in 1:1 molar ratio, leads to the formation of the polymeric complex {[SbCl3(HDTOA)(1.5)]}(n) (1). The complex was characterized by FT-IR spectroscopy, H-1,C-13 NMR spectroscopy and TG-DTA analysis. Crystal and molecular structure of I was determined by X-ray diffraction analysis. Complex 1 ([C21H36Cl3N3S3Sb]) crystallizes in trigonal space group, with a = 13.8829(2) angstrom, b = 13.8829(2) angstrom, c = 27.3440(5) angstrom, alpha = 90.00 degrees, beta = 90.000 degrees, gamma = 120.00 degrees and Z= 12. The complex is polymeric consisting by [SbCl3(HDTOA)(1.5)] building blocks. The octahedral geometric demand of the metal center is covered by three mutually cis chlorides and three sulfur atoms from three different HDTOA ligands. Each HDTOA ligand bridged two metal centers of two units through their sulfur donor atoms, acting as bidentate bridging ligand forming a 3D network. Complex 1 was also, evaluated for its in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) cell lines. The ID50 values were higher than the corresponding of cisplatin against these cell lines. Partial Least Squares (PLS) regression analysis was carried out to correlate the variation of the ID50 values (Y-variables) with the variations of energetic parameters (X-variables), calculated from molecular docking calculation. (C) 2012 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipNamik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.10.AR.10.1]
dc.description.sponsorshipI.I.O and O.S.U. acknowledge the financial support from Namik Kemal University Scientific Research Project (Project No. NKUBAP.00.10.AR.10.1).
dc.identifier.doi10.1016/j.poly.2012.04.038
dc.identifier.endpage1410
dc.identifier.issn0277-5387
dc.identifier.scopus2-s2.0-84875422034
dc.identifier.scopusqualityQ2
dc.identifier.startpage1403
dc.identifier.urihttps://doi.org/10.1016/j.poly.2012.04.038
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7157
dc.identifier.volume52
dc.identifier.wosWOS:000318747100175
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorÖztürk, İbrahim İsmet
dc.institutionauthorÜrgüt, Ozan
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPolyhedron
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBioinorganic chemistry
dc.subjectAntimony(III) complexes
dc.subjectN,N-Dicyclohexyldithiooxamide ligand
dc.subjectCrystal structure
dc.subjectCytotoxicity
dc.subjectOxamide Metal-Complexes
dc.subjectMolecular-Structures
dc.subjectDithio-Oxamides
dc.subjectCrystal
dc.subjectThioamides
dc.subjectLigands
dc.subjectThiones
dc.subjectDioxamide
dc.subjectElements
dc.subjectState
dc.titleSynthesis, structural characterization and cytotoxicity of the antimony(III) chloride complex with N,N-dicyclohexyldithiooxamide
dc.typeArticle

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