Synthesis, structural characterization and cytotoxicity of the antimony(III) chloride complex with N,N-dicyclohexyldithiooxamide
Yükleniyor...
Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The reaction of antimony(III) chloride with the bidentate substituted dithiooxamide ligand, N,N-dicyclohexyldithiooxamide (HDTOA), in 1:1 molar ratio, leads to the formation of the polymeric complex {[SbCl3(HDTOA)(1.5)]}(n) (1). The complex was characterized by FT-IR spectroscopy, H-1,C-13 NMR spectroscopy and TG-DTA analysis. Crystal and molecular structure of I was determined by X-ray diffraction analysis. Complex 1 ([C21H36Cl3N3S3Sb]) crystallizes in trigonal space group, with a = 13.8829(2) angstrom, b = 13.8829(2) angstrom, c = 27.3440(5) angstrom, alpha = 90.00 degrees, beta = 90.000 degrees, gamma = 120.00 degrees and Z= 12. The complex is polymeric consisting by [SbCl3(HDTOA)(1.5)] building blocks. The octahedral geometric demand of the metal center is covered by three mutually cis chlorides and three sulfur atoms from three different HDTOA ligands. Each HDTOA ligand bridged two metal centers of two units through their sulfur donor atoms, acting as bidentate bridging ligand forming a 3D network. Complex 1 was also, evaluated for its in vitro cytotoxic activity against leiomyosarcoma (LMS) and human breast adenocarcinoma (MCF-7) cell lines. The ID50 values were higher than the corresponding of cisplatin against these cell lines. Partial Least Squares (PLS) regression analysis was carried out to correlate the variation of the ID50 values (Y-variables) with the variations of energetic parameters (X-variables), calculated from molecular docking calculation. (C) 2012 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Bioinorganic chemistry, Antimony(III) complexes, N,N-Dicyclohexyldithiooxamide ligand, Crystal structure, Cytotoxicity, Oxamide Metal-Complexes, Molecular-Structures, Dithio-Oxamides, Crystal, Thioamides, Ligands, Thiones, Dioxamide, Elements, State
Kaynak
Polyhedron
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
52
