Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative

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dc.authorid0000-0003-1405-2920
dc.authorid0000-0002-0064-8400
dc.authorid0000-0002-0064-8400
dc.authorscopusid57204525185
dc.authorscopusid56268532500
dc.authorscopusid36085857200
dc.authorscopusid25630447400
dc.authorwosidUZGÖREN-BARAN, AYŞE/G-9260-2013
dc.authorwosidTASKIN TOK, Tugba/A-8885-2016
dc.authorwosidTok, Tugba Taskin/M-5740-2019
dc.contributor.authorÖzkan, Şule
dc.contributor.authorTaşkın Tok, Tuğba
dc.contributor.authorUzgören Baran, Ayşe
dc.contributor.authorAkbay, Nuriye
dc.date.accessioned2022-05-11T14:31:01Z
dc.date.available2022-05-11T14:31:01Z
dc.date.issued2019
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractMode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular dichroism spectroscopy. It is concluded that TAH could intercalate into the base pairs of ct-DNA, and the fluorescence quenching by ct-DNA was static quenching type. Beside the multispectroscopic results, computational studies were done. Molecular docking results revealed that the TAH-DNAs complexes might be classified as druggable molecule in drug design. Additionally, DNA binding studies exhibited that TAH complexes have different interaction and orientation abilities to each DNA isomer. Combination of experimental and computational data showed that reported TAH is promising structure and deserves further applications.
dc.description.sponsorshipScientific and Technical Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z391]
dc.description.sponsorshipThis work was supported by the Scientific and Technical Research Council of Turkey (TUBITAK) - Grant No 114Z391.
dc.identifier.doi10.1007/s10895-018-2314-4
dc.identifier.endpage110
dc.identifier.issn1053-0509
dc.identifier.issn1573-4994
dc.identifier.issue1en_US
dc.identifier.pmid30361860
dc.identifier.scopus2-s2.0-85055929660
dc.identifier.scopusqualityQ1
dc.identifier.startpage101
dc.identifier.urihttps://doi.org/10.1007/s10895-018-2314-4
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7284
dc.identifier.volume29
dc.identifier.wosWOS:000462475000010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan, Şule
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofJournal of Fluorescence
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFluorescence
dc.subjectct-DNA
dc.subjectTetrahydrocabazoles
dc.subjectStern-Volmer
dc.subjectGroove binding
dc.subjectFluorescent-Probe
dc.subjectGroove Binding
dc.subjectDesign
dc.subjectAnalog
dc.titleMultispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative
dc.typeArticle

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