Multispectroscopic and Computational Investigation of ct-DNA Binding Properties with Hydroxybenzylidene Containing Tetrahydrocarbazole Derivative
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Springer/Plenum Publishers
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
Mode of interaction of a new tetrahydrocarbazole derivative with ct-DNA has been investigated systematically using fluorescence spectroscopy, UV-Vis spectroscopy and circular dichroism spectroscopy. It is concluded that TAH could intercalate into the base pairs of ct-DNA, and the fluorescence quenching by ct-DNA was static quenching type. Beside the multispectroscopic results, computational studies were done. Molecular docking results revealed that the TAH-DNAs complexes might be classified as druggable molecule in drug design. Additionally, DNA binding studies exhibited that TAH complexes have different interaction and orientation abilities to each DNA isomer. Combination of experimental and computational data showed that reported TAH is promising structure and deserves further applications.
Description
Keywords
Fluorescence, ct-DNA, Tetrahydrocabazoles, Stern-Volmer, Groove binding, Fluorescent-Probe, Groove Binding, Design, Analog
Journal or Series
Journal of Fluorescence
WoS Q Value
Q3
Scopus Q Value
Q1
Volume
29
Issue
1
