Are biological agents toxic to human chondrocytes and osteocytes?

Basit Öğe Kaydı
dc.authorid0000-0003-2003-6337
dc.authorid0000-0003-2112-4056
dc.authorid0000-0001-9052-4411
dc.authorscopusid56258081800
dc.authorscopusid56715752200
dc.authorscopusid35197435300
dc.authorscopusid23102238400
dc.authorscopusid56769801000
dc.authorscopusid57191926529
dc.authorscopusid56002899200
dc.authorwosidsirin, duygu yasar/AAR-8685-2020
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.authorwosidMahirogullari, Mahir/AAA-4742-2020
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidISYAR, Mehmet/O-9019-2016
dc.contributor.authorİşyar, Mehmet
dc.contributor.authorBilir, Bülent
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorÇakmak, Selami
dc.contributor.authorŞirin, Duygu Yaşar
dc.contributor.authorYıldırım Güzelant, Aliye
dc.contributor.authorMahiroğulları, Mahir
dc.date.accessioned2022-05-11T14:10:03Z
dc.date.available2022-05-11T14:10:03Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Biyoloji Bölümü
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Fizik Tedavi ve Rehabilitasyon Ana Bilim Dalı
dc.description.abstractPurpose: The aim of the present study is to investigate the effects of biological agents (BAs) on human chondrocytes and osteocytes in vitro. Methods: Primary cell cultures obtained from gonarthrosis patients were divided into four groups, two of which were designated as control cultures of chondrocyte and osteocyte, and the other two groups were exposed to BAs administered via the culture medium. Cultured cells were characterized by immunophenotyping. Before and after administration of the agents, the cultures were observed by inverted and environmental scanning electron microscopy (ESEM). The number of live cells and the proliferation rate were monitored by MTT assay. Results: Rituximab and adalimumab were the least toxic agents to chondrocytes, whereas adalimumab and etanercept were to osteocytes. Conclusion: During periods of intense active inflammation, the concentration of the preferred BAs after inhibition of inflammation needs to be emphasized when their effects on cartilage and bone tissue are considered at the cellular level if the clinical practice is to continue.
dc.identifier.doi10.1186/s13018-015-0264-y
dc.identifier.issn1749-799X
dc.identifier.pmid26223355
dc.identifier.scopus2-s2.0-84938880575
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1186/s13018-015-0264-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5263
dc.identifier.volume10
dc.identifier.wosWOS:000358640500001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilir, Bülent
dc.institutionauthorŞirin, Duygu Yaşar
dc.institutionauthorYıldırım Güzelant, Aliye
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofJournal of Orthopaedic Surgery and Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiological agents
dc.subjectChondrotoxicity
dc.subjectOsteotoxicity
dc.subjectPrimary cell culture
dc.subjectRheumatoid-Arthritis
dc.subjectLocal-Anesthetics
dc.subjectAdalimumab
dc.subjectAbatacept
dc.subjectTocilizumab
dc.subjectInfliximab
dc.subjectRituximab
dc.subjectEfficacy
dc.subjectAnakinra
dc.subjectDiseases
dc.titleAre biological agents toxic to human chondrocytes and osteocytes?
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5263.pdf
Boyut:
2.3 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Fen Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu