The effect of melatonin in rats with uterine torsion on uterus contractions, and the levels of ADMA, SDMA, arginine, Hsp90, TLR4, and NF-?B

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dc.authorid0000-0001-5653-0025
dc.authorscopusid57194180999
dc.authorscopusid6602416499
dc.authorscopusid16242768200
dc.authorscopusid36916673100
dc.authorscopusid57208049553
dc.authorscopusid9038072400
dc.authorscopusid56412874000
dc.authorwosidGul, Huseyin Fatih/AAN-7673-2021
dc.authorwosidDOĞAN, Halef/AAA-9951-2020
dc.authorwosidRisvanli, Ali/W-5667-2018
dc.contributor.authorDoğan, Halef
dc.contributor.authorRisvanli, Ali
dc.contributor.authorSaat, Nevzat
dc.contributor.authorGül, Hüseyin Fatih
dc.contributor.authorİlhan, Necip
dc.contributor.authorSeker, İbrahim
dc.contributor.authorSahna, Engin
dc.date.accessioned2022-05-11T14:42:14Z
dc.date.available2022-05-11T14:42:14Z
dc.date.issued2019
dc.departmentFakülteler, Veteriner Fakültesi, Klinik Bilimler Bölümü, Doğum ve Jinekoloji Ana Bilim Dalı
dc.description.abstractIn this study was aimed at reducing uterine damage and increasing fertility after uterine torsion in pregnant animals. With this aim, uterine torsion was experimentally formed in 35 rats that were between 18-19 days pregnant. The animals were randomly divided into five groups, and melatonin was administered prior to torsion, at the time of torsion, and detorsion (10 mg/kg/gun IP). Ovario-hysterectomy operation was performed on all animals on the first day following parturition. Subsequently, from the obtained uterus samples, determination of the levels of asymmetrical dimethyl arginin (ADMA), symmetrical dimethyl arginin (SDMA), and arginine was made using the high-performance liquid chromatography (HPLC) and levels of Heat shock protein 90 (Hsp90), TLR4 (Toll Like Receptor 4) and NF kappa B (Nuclear factor kappa-light-chain-enhancer of activated B cells) were measured using the Western blot technique. The contraction-relaxation responses of the myometrium were also determined in the organ baths. According to the results of the western blot, higher protein expressions than those of the control group were determined in the second, third, fourth, and fifth groups in Hsp90, TLR4, NF-kappa B. The lowest values of arginine and ADMA were found in Group 3, whilst the lowest SDMA value was determined in Group 1. It was determined that melatonin reduces tissue damage secondary to torsio uteri and, furthermore, that administration of this hormone at the time of torsion formation was more effective than its administration at the time of detorsion.
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TUBITAK - 115O381]
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK - 115O381).
dc.identifier.doi10.33988/auvfd.467062
dc.identifier.endpage272
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85077048481
dc.identifier.scopusqualityQ3
dc.identifier.startpage267
dc.identifier.urihttps://doi.org/10.33988/auvfd.467062
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9297
dc.identifier.volume66
dc.identifier.wosWOS:000472627700007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDoğan, Halef
dc.language.isoen
dc.publisherAnkara Univ Press
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMelatonin
dc.subjectpregnancy
dc.subjectrats
dc.subjecttorsion
dc.subjectuterine
dc.subjectInjury
dc.subjectDetorsion
dc.subjectDamage
dc.subjectOvary
dc.titleThe effect of melatonin in rats with uterine torsion on uterus contractions, and the levels of ADMA, SDMA, arginine, Hsp90, TLR4, and NF-?B
dc.title.alternativeThe effect of melatonin in rats with uterine torsion on uterus contractions, and the levels of ADMA, SDMA, arginine, Hsp90, TLR4, and NF-kappa B
dc.typeArticle

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