Ultrasound phantom with solids mimicking cancerous tissue for needle breast biopsy

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dc.contributor.authorYayla, Işık İpek Avcı
dc.contributor.authorBilal, Melis
dc.contributor.authorSalmaslıoğlu, Artur
dc.contributor.authorErçağ, Erol
dc.contributor.authorSezer, Esma
dc.contributor.authorUstamehmetoğlu, Belkıs
dc.date.accessioned2023-05-06T17:20:49Z
dc.date.available2023-05-06T17:20:49Z
dc.date.issued2022
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractThis study aimed at synthesizing hydrogels to simulate opaque breast tissue (BT) and coloured cancerous tissues (CT) at different densities of the designed phantom to improve the biopsy-related skills along with ultrasonography. Both tissues are tear-resistant and therefore, the phantom can be trained multiple times in order to lower the price and improve the eye-hand coordination of users. For this purpose, self-healing (SH) polyacrylamide (PAAm) hydrogels (SH hydrogel) obtained by free-radical polymerization of AAm, in the presence of chemical cross-linker, BAAm, physical cross-linker stearyl methacrylate, C18, and ammonium persulfate APS as initiator were used in the design of phantoms. Psyllium was added to the BT to differentiate density and obtain human skin color and it could be distinguished from the CT which was also colored with methyl violet. BT and CTs were characterized with FTIR spectroscopy, mechanical, swelling, and refractive index measurements. Designing phantoms from BT and CT were characterized by ultrasonography, mechanical tests, observation of needle track after biopsy, and stabilization tests to follow the self-healing behaviours of tissues with time. As a result of this study, self-healing, low-cost, and suitable for multi-usage ultrasonographic phantom for needle breast biopsy was designed and cancerous tissue was successfully detected.
dc.description.sponsorship[214S357]
dc.description.sponsorshipAcknowledgements We thank T?B?TAK, which supported our work with project number of 214S357. Many thanks to Dentist Dr. Hayri Bingeli for their help with molding the hydrogels.
dc.identifier.doi10.55730/1300-0527.3454
dc.identifier.endpage1503
dc.identifier.issn1300-0527
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85143146734
dc.identifier.scopusqualityQ3
dc.identifier.startpage1493
dc.identifier.trdizinid1142219
dc.identifier.urihttps://doi.org/10.55730/1300-0527.3454
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11963
dc.identifier.volume46
dc.identifier.wosWOS:000876350600012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorErçağ, Erol
dc.language.isoen
dc.publisherScientific And Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSelf-healing polyacrylamide hydrogels
dc.subjectpsyllium
dc.subjectcancerous tissue containing breast phantom
dc.subjectultrasonographic biopsy
dc.subjectSelf-Healing Hydrogels
dc.subjectTough
dc.subjectBehavior
dc.subjectGelatin
dc.subjectGel
dc.titleUltrasound phantom with solids mimicking cancerous tissue for needle breast biopsy
dc.typeArticle

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