An Effective Approach to the Strychnos Alkaloids: Total Synthesis of Tubifolidine

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dc.authorscopusid6507868758
dc.contributor.authorUludağ, Nesimi
dc.date.accessioned2022-05-11T14:31:05Z
dc.date.available2022-05-11T14:31:05Z
dc.date.issued2021
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA facile total synthesis of tubifolidine has been developed, which is accomplished in an 11-step synthesis of the ABCDE pentacyclic of the strychnos alkaloids with an overall yield of 10%. The key steps are the cyclization reaction for starting tetrahydrocarbazoles bearing a nitrilealkyl side chain at the C-2 position, mediated by tetrachloro-1,4-benzoquinone (TCB) and the intramolecular addition of the amide as the nucleophile. This cyclization reaction was obtained with the relevant architecture, including strychnos skeletal-type alkaloids.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T503]
dc.description.sponsorshipFinancial support for this research from the Scientific and Technological Research Council of Turkey (TUBITAK Project No. 112T503) is acknowledged.
dc.identifier.doi10.1007/s10600-021-03394-y
dc.identifier.endpage496
dc.identifier.issn0009-3130
dc.identifier.issn1573-8388
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85106686449
dc.identifier.scopusqualityQ3
dc.identifier.startpage491
dc.identifier.urihttps://doi.org/10.1007/s10600-021-03394-y
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7312
dc.identifier.volume57
dc.identifier.wosWOS:000655545300004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorUludağ, Nesimi
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofChemistry of Natural Compounds
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectindole
dc.subjecttubifolidine
dc.subjectstrychnos alkaloids
dc.subjectazocino[4
dc.subject3-b]indole
dc.subjectConcise Total-Synthesis
dc.subjectFt-Ir
dc.subjectFramework
dc.subjectEntry
dc.subjectRoute
dc.subjectCore
dc.subjectMep
dc.subjectNmr
dc.subjectNlo
dc.subjectNbo
dc.titleAn Effective Approach to the Strychnos Alkaloids: Total Synthesis of Tubifolidine
dc.typeArticle

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