An Effective Approach to the Strychnos Alkaloids: Total Synthesis of Tubifolidine
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A facile total synthesis of tubifolidine has been developed, which is accomplished in an 11-step synthesis of the ABCDE pentacyclic of the strychnos alkaloids with an overall yield of 10%. The key steps are the cyclization reaction for starting tetrahydrocarbazoles bearing a nitrilealkyl side chain at the C-2 position, mediated by tetrachloro-1,4-benzoquinone (TCB) and the intramolecular addition of the amide as the nucleophile. This cyclization reaction was obtained with the relevant architecture, including strychnos skeletal-type alkaloids.
Açıklama
Anahtar Kelimeler
indole, tubifolidine, strychnos alkaloids, azocino[4, 3-b]indole, Concise Total-Synthesis, Ft-Ir, Framework, Entry, Route, Core, Mep, Nmr, Nlo, Nbo
Kaynak
Chemistry of Natural Compounds
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
57
Sayı
3
