Development and validation of a sensitive spectrofluorimetric method for the determination of cilazapril of human plasma, urine, in pure and pharmaceutical preparations

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dc.authorid0000-0003-2759-4411
dc.authorscopusid55235059200
dc.authorwosidkarasakal, ayca/ABA-4762-2020
dc.contributor.authorKarasakal, Ayça
dc.date.accessioned2022-05-11T14:30:52Z
dc.date.available2022-05-11T14:30:52Z
dc.date.issued2015
dc.departmentFakülteler, Fen Edebiyat Fakültesi, Kimya Bölümü
dc.description.abstractA selective and sensitive spectrofluorimetric method was developed and validated for the determination of cilazapril in human plasma urine, in pure and pharmaceutical preparations. The proposed method is based on derivatization using 1-dimethylaminonaphthalene-5-sulphonyl chloride (dansyl chloride) as fluorogenic agent and measuring the fluorescence of the products at emission wavelengths of 503 nm after excitation at 374 nm. The method was validated for linearity, limit of detection, limit of quantification, precision, accuracy, recovery. The calibration curves were linear over a concentration range of 100-500 and 50-250 ng/mL for plasma and urine, respectively. The limits of detection were calculated to be 0.26 and 31.59 ng/mL for plasma and urine, respectively. The proposed method was applied to study of cilazapril in pure, human plasma, urine, and pharmaceutical preparations.
dc.identifier.doi10.1134/S0030400X15080111
dc.identifier.endpage326
dc.identifier.issn0030-400X
dc.identifier.issn1562-6911
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84940100403
dc.identifier.scopusqualityQ4
dc.identifier.startpage322
dc.identifier.urihttps://doi.org/10.1134/S0030400X15080111
dc.identifier.urihttps://hdl.handle.net/20.500.11776/7197
dc.identifier.volume119
dc.identifier.wosWOS:000360091600026
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKarasakal, Ayça
dc.language.isoen
dc.publisherMaik Nauka/Interperiodica/Springer
dc.relation.ispartofOptics and Spectroscopy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPerformance Liquid-Chromatography
dc.subjectActive Metabolite Cilazaprilat
dc.subjectEnzyme-Inhibitor Cilazapril
dc.subjectQuantitative-Determination
dc.subjectHydrochlorothiazide
dc.subjectFormulations
dc.titleDevelopment and validation of a sensitive spectrofluorimetric method for the determination of cilazapril of human plasma, urine, in pure and pharmaceutical preparations
dc.typeArticle

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