Evaluation of the genetic resistance status to classical and atypical scrapie in Karacabey merino rams

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dc.authorid0000-0002-9992-8102
dc.authorid0000-0003-2705-2831
dc.authorscopusid56201904300
dc.authorscopusid6701528877
dc.authorscopusid24779770200
dc.authorwosidün, cemal/AAH-3099-2020
dc.authorwosidYAMAN, Yalçın/AAH-3642-2019
dc.authorwosidSoysal, Mehmet İhsan/ABA-4699-2020
dc.contributor.authorYaman, Yalçın
dc.contributor.authorSoysal, Mehmet İhsan
dc.contributor.authorÜn, Cemal
dc.date.accessioned2022-05-11T14:46:32Z
dc.date.available2022-05-11T14:46:32Z
dc.date.issued2015
dc.departmentFakülteler, Ziraat Fakültesi, Zootekni Bölümü
dc.description.abstractScrapie, the oldest prion disease of sheep, has two types: classical and atypical scrapie. It was determined that some nucleotide polymorphisms in the PrP coding gene have affected classical and atypical scrapie susceptibility. Consequently, EU member states have established breeding programs aiming to increase genetic resistance of their flocks to classical scrapie. These breeding programs have primarily been implemented in economically important breeds. Thus, we investigated classical and atypical scrapie related PrP genotypes of the Karacabey merino breed, which is of great economic importance in western regions of Turkey. In relation to classical scrapie, three alleles (ARR, ARQ, and VRQ) and five genotypes (ARR/ARR, ARR/ARQ, ARQ/ARQ, ARR/VRQ, and ARQ/VRQ) were identified. Frequencies were found to be 0.280, 0.677, and 0.043 for the alleles and 0.086, 0.376, 0.452, 0.011, and 0.075 for the genotypes, respectively. In terms of atypical scrapie, four alleles (ALRR, ALRQ, AFRQ, and VLRQ) and eight genotypes (ALRR/ALRR, ALRR/AFRQ, ALRR/ALRQ, ALRQ/AFRQ, ALRQ/ALRQ, VLRQ/ALRR, VLRQ/ALRQ, and VLRQ/AFRQ) were identified. Frequencies were found to be 0.272, 0.636, 0.049, and 0.043 for the alleles and 0.076, 0.033, 0.348, 0.043, 0.413, 0.011, 0.054, and 0.022 for the genotypes, respectively. Three nonsynonymous and two silent additional polymorphisms were also determined along with the PrP coding gene.
dc.description.sponsorshipGeneral Directorate of Agricultural Research and Policies of Republic of Turkey Ministry of Food, Agriculture and LivestockGida Tarim Ve Hayvancilik Bakanligi
dc.description.sponsorshipThis research was carried out at the Sheep Research Institute Bandirma, Balikesir, Turkey. Research was funded by the General Directorate of Agricultural Research and Policies of Republic of Turkey Ministry of Food, Agriculture and Livestock.
dc.identifier.doi10.3906/vet-1507-36
dc.identifier.endpage740
dc.identifier.issn1300-0128
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-84947928475
dc.identifier.scopusqualityQ3
dc.identifier.startpage736
dc.identifier.urihttps://doi.org/10.3906/vet-1507-36
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10319
dc.identifier.volume39
dc.identifier.wosWOS:000365509400017
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorSoysal, Mehmet İhsan
dc.language.isoen
dc.publisherScientific Technical Research Council Turkey-Tubitak
dc.relation.ispartofTurkish Journal of Veterinary & Animal Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectKaracabey merino
dc.subjectclassical scrapie
dc.subjectatypical scrapie
dc.subjectPrP gene
dc.subjectpolymorphims
dc.subjectPrion Protein Gene
dc.subjectCreutzfeldt-Jakob-Disease
dc.subjectPrp Genotypes
dc.subjectSheep
dc.subjectPolymorphisms
dc.subjectVariability
dc.subjectRisk
dc.titleEvaluation of the genetic resistance status to classical and atypical scrapie in Karacabey merino rams
dc.typeArticle

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