The Identification of Novel Single-Nucleotide Polymorphisms of Equine Beta-Lactoglobulin and Lactotransferrin Genes

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dc.authorscopusid57200696504
dc.contributor.authorIşık, Raziye
dc.date.accessioned2022-05-11T14:07:11Z
dc.date.available2022-05-11T14:07:11Z
dc.date.issued2019
dc.departmentFakülteler, Ziraat Fakültesi, Tarımsal Biyoteknoloji Bölümü
dc.description.abstractLactoferrin (LTF), also called lactotransferrin, is an iron-binding protein and member of transferrin family, whereas ?-LG is an important milk protein and belongs to the ligand-binding protein family of lipocalins and binds retinol. Beta-lactoglobulin (?-LG) is a major whey protein and it is a member of lipocalins family. ?-LG is also known as a major allergen reason of cow milk protein allergy. Yet, no information has been reported about ?-LG and LTF genes in donkeys. In this study, the genetic variation of ?-LG and LTF genes were analyzed via DNA sequencing in 77 donkeys, which were individuals reared in Thrace region of Turkey. Four novel SNPs are identified as g.12887G>A, g.12973G>A, g.12654G>A, and g.13057T>C in the third intron region of ?-LG gene and a genetic variant g.272719G>A in the 14th intron of LTF gene. The DNA sequences of ?-LG and LTF genes in donkeys are reported for the first time in this study and these sequences were deposited to NCBI GenBank database, with the accession number MK125015 and MK211165, respectively. These variations may have an effect on milk yield and content in donkeys, so further investigations are needed to prove this hypothesis and these may be candidate SNPs for donkey breeding. © 2019 Elsevier Inc.
dc.identifier.doi10.1016/j.jevs.2019.01.005
dc.identifier.endpage64
dc.identifier.issn0737-0806
dc.identifier.pmid31002094
dc.identifier.scopus2-s2.0-85061553737
dc.identifier.scopusqualityQ2
dc.identifier.startpage60
dc.identifier.urihttps://doi.org/10.1016/j.jevs.2019.01.005
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5000
dc.identifier.volume75
dc.identifier.wosWOS:000465042100011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorIşık, Raziye
dc.language.isoen
dc.publisherW.B. Saunders
dc.relation.ispartofJournal of Equine Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDNA sequencing
dc.subjectDonkey
dc.subjectEquus asinus
dc.subjectLTF gene
dc.subject?-LG gene
dc.subjectbeta lactoglobulin
dc.subjectlactoferrin
dc.subjectlactoferrin
dc.subjectlactoglobulin
dc.subjectnucleotide
dc.subjectArticle
dc.subjectDNA sequence
dc.subjectdonkey
dc.subjectgene identification
dc.subjectgenetic variability
dc.subjectgenetic variation
dc.subjectintron
dc.subjectmilk yield
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectsingle nucleotide polymorphism
dc.subjectTurkey (republic)
dc.subjectanimal
dc.subjectbovine
dc.subjectEquidae
dc.subjectfemale
dc.subjectgenetics
dc.subjecthorse
dc.subjectturkey (bird)
dc.subjectAnimals
dc.subjectCattle
dc.subjectEquidae
dc.subjectFemale
dc.subjectHorses
dc.subjectLactoferrin
dc.subjectLactoglobulins
dc.subjectNucleotides
dc.subjectPolymorphism, Single Nucleotide
dc.subjectTurkey
dc.titleThe Identification of Novel Single-Nucleotide Polymorphisms of Equine Beta-Lactoglobulin and Lactotransferrin Genes
dc.typeArticle

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